{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:01:51Z","timestamp":1791273711394,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid spread of the severe acute respiratory syndrome\u2010coronavirus\u20102 (SARS\u2010CoV\u20102) virus has left many health systems around the world overwhelmed, forcing triaging of scarce medical resources. Identifying indicators of hospital admission for coronavirus disease 2019 (COVID\u201019) patients early in the disease course could aid the efficient allocation of medical interventions. Self\u2010reported olfactory impairment has recently been recognized as a hallmark of COVID\u201019 and may be an important predictor of clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of all patients presenting to a San Diego Hospital system with laboratory\u2010confirmed positive COVID\u201019 infection was conducted with evaluation of olfactory and gustatory function and clinical disease course. Univariable and multivariable logistic regression were performed to identify risk factors for hospital admission and anosmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 169 patients tested positive for COVID\u201019 disease between March 3 and April 8, 2020. Olfactory and gustatory data were obtained for 128 (75.7%) of 169 subjects, of which 26 (20.1%) of 128 required hospitalization. Admission for COVID\u201019 was associated with intact sense of smell and taste, increased age, diabetes, and subjective and objective parameters associated with respiratory failure. On adjusted analysis, anosmia was strongly and independently associated with outpatient care (adjusted odds ratio [aOR] 0.09; 95% CI, 0.01\u20100.74), whereas positive findings of pulmonary infiltrates and\/or pleural effusion on chest radiograph (aOR 8.01; 95% CI, 1.12\u201057.49) was strongly and independently associated with admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Normosmia is an independent predictor of admission in COVID\u201019 cases. Smell loss in COVID\u201019 may be associated with a milder clinical course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22592","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T04:18:15Z","timestamp":1587701895000},"page":"821-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":281,"title":["Self\u2010reported olfactory loss associates with outpatient clinical course in COVID\u201019"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-4922","authenticated-orcid":false,"given":"Carol H.","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhoud","family":"Faraji","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya P.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"},{"name":"School of Medicine University of California San Diego  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Ostrander","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"DeConde","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  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