{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T18:26:16Z","timestamp":1748370376826,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aspirin\u2010exacerbated respiratory disease (AERD) represents a severe endotype of chronic rhinosinusitis with nasal polyposis. Although aspirin desensitization (AD) has emerged as an effective therapeutic option, the natural history of AERD without AD remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was conducted of AERD patients who underwent endoscopic sinus surgery (ESS) without AD between 2010 and 2019. The primary outcomes were revision surgery rate and time to revision surgery. Secondary outcomes included changes in 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) scores and Lund\u2010Kennedy endoscopy scores (LKES). A subgroup analysis was performed for patients on monoclonal antibody therapy (MAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 141 patients, 37 (26.2%) underwent revision ESS with a median time to revision of 3.3 (interquartile range [IQR], 2.2\u20104.9) years. The probability of remaining free of revision surgery at 1, 3, and 5 years was: 98.2% (95% confidence interval [CI], 95.7\u2010100.0%), 78.8% (95% CI, 70.2\u201088.4%), and 44.8% (95% CI, 32.4\u201062.1%), respectively. SNOT\u201022 scores decreased by 34 (IQR, 18\u201052) points at 6 months and 27 (IQR, 20\u201046) points at 1 year postoperatively. In the revision cohort, the decrease in SNOT\u201022 score was not sustained at 1 year postoperatively. No difference was found in time to revision compared with those without MAT (<jats:italic>p<\/jats:italic> = 0.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant proportion of AERD patients benefit from ESS and medical therapy alone without AD. This study presents preliminary results on the impact of MAT on surgical outcomes as it is limited by the small sample size. Further research on the use of MAT in AERD is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22626","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T19:05:51Z","timestamp":1592507151000},"page":"1149-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical outcomes in aspirin\u2010exacerbated respiratory disease without aspirin desensitization"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-3474","authenticated-orcid":false,"given":"Elysia","family":"Grose","sequence":"first","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head &amp; Neck Surgery, St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-2858","authenticated-orcid":false,"given":"Daniel J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head &amp; Neck Surgery, St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head &amp; Neck Surgery, St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Cottrell","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head &amp; Neck Surgery, St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Sykes","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre, Department of Respirology St. Michael's Hospital  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Toronto Allergists  Toronto ON Canada"},{"name":"Evidence Based Medical Educator  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-4674","authenticated-orcid":false,"given":"John M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head &amp; Neck Surgery, St. Michael's Hospital University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4188"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22487"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816640723"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22428"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22471"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.05.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22473"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.047"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkThoracJ.2018.17109"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4241"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.044"},{"issue":"63","key":"e_1_2_6_16_1","first-page":"RCT3783","article-title":"Dupilumab (DPL) efficacy in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with\/without nonsteroidal anti\u2010inflammatory drug\u2010exacerbated respiratory disease (NSAID\u2010ERD): SINUS\u201024, SINUS\u201052 Trials. In: Airway pharmacology and treatment","volume":"54","author":"Mullol J","year":"2019","journal-title":"Eur Respir J"},{"key":"e_1_2_6_17_1","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld RM","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-2"},{"key":"e_1_2_6_19_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention 2020. Available from:http:\/\/www.ginasthma.org. Accessed May 18 2020."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01009.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-11412-0_12"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12131"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418770260"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22036"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545750"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21739"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000304"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22505"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22626","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:59:19Z","timestamp":1693810759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/alr.22626"],"URL":"https:\/\/doi.org\/10.1002\/alr.22626","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"type":"print","value":"2042-6976"},{"type":"electronic","value":"2042-6984"}],"subject":[],"published":{"date-parts":[[2020,6,18]]},"assertion":[{"value":"2020-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}