{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:04:34Z","timestamp":1787321074197,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560172"],"award-info":[{"award-number":["81560172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860186"],"award-info":[{"award-number":["81860186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970858"],"award-info":[{"award-number":["81970858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common heterogenous disease in the patients with chronic airway diseases. This study investigated the role of blood eosinophil count (BEC) in the classification of CRSwNP and its recurrence in eosinophilic CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010five patients who underwent nasal endoscopic resection of CRSwNP were recruited and divided into eosinophilic CRSwNP and non\u2010eosinophilic CRSwNP groups based on the levels (10% cutoff) of eosinophil infiltration as indicated by hematoxylin and eosin (H&amp;E) staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We recruited 30 patients in the eosinophilic CRSwNP group and 35 patients in the non\u2010eosinophilic CRSwNP group. The outcome of preoperative visual analogue scale (VAS) score, preoperative Lund\u2010Mackay score, and preoperative Lund\u2010Kennedy score between the 2 groups were comparable. The level of BEC in the eosinophilic CRSwNP group was significantly higher than that of non\u2010eosinophilic CRSwNP group (0.79 \u00b1 0.27 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L vs 0.30 \u00b1 0.22 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). We observed a statistical significance in the number of H&amp;E eosinophils (29.11 \u00b1 2.93 vs 3.17 \u00b1 0.51;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and CRSwNP phenotypes (eosinophilic\/non\u2010eosinophilic, 28\/3 vs 2\/32;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) when the cutoff value of BEC was set at 0.39 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L. The disease\u2010free recurrence (DFR) was found to be statistically significant when the cutoff value of BEC was 0.73 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L in eosinophilic CRSwNP (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results indicate that BEC may be capable of distinguishing CRSwNP phenotypes as well as predicting polyp recurrence in eosinophilic CRSwNP. Given the relatively small sample size, further studies will be necessary to confirm a role for BEC as a systemic biomarker in CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22636","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T13:54:39Z","timestamp":1594130079000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of preoperative blood eosinophil counts in distinguishing chronic rhinosinusitis with nasal polyps phenotypes"],"prefix":"10.1002","volume":"11","author":[{"given":"Bing","family":"Zhong","sequence":"first","affiliation":[{"name":"Upper Airways Research Laboratory, Department of Otolaryngology\u2013Head and Neck Surgery, West China Hospital Sichuan University  Chengdu Sichuan 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