{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:52:29Z","timestamp":1770285149559,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal obstruction is a common complaint in patients with sleep\u2010disordered breathing and obstructive sleep apnea (OSA). Although topical nasal treatments (TNTs) have been shown to reduce nasal resistance and improve nasal obstruction, there is conflicting evidence regarding the role of TNTs in adult OSA. In this systematic review and meta\u2010analysis we aim to evaluate the role of TNTs in adults with OSA. Data sources used included PubMed, Ovid MEDLINE, and Cochrane Central, from January 2001 to July 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion criteria were English\u2010language studies containing original data on TNTs in adults (\u226518 years) with OSA (apnea\u2010hypopnea index [AHI] \u22655). Exclusion criteria were case reports, studies without outcome measures, and concurrent non\u2010TNT treatment for OSA. Two investigators independently reviewed all articles and performed quality assessment using validated tools. Meta\u2010analysis and quality assessment were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2180 abstracts identified, 8 studies met inclusion criteria. TNTs included decongestants (4 of 8 studies), corticosteroids (3 of 8), and antihistamines (1 of 8). Outcome measures included AHI (8 of 8), respiratory distress index (RDI; 1 of 8), oxygen\u2010desaturation index (ODI; 3 of 8), minimum SaO2 (MinSaO<jats:sub>2<\/jats:sub>; 4 of 8), nasal resistance (4 of 8), endoscopic sinus surgery (4 of 8 studies) and standardized rhinoconjunctivitis quality of life questionnaire scores (1 of 8 studies). Qualitatively, all studies showed trends toward improving objective and subjective measures of OSA, although the significance of these improvements varied across studies. A meta\u2010analysis was performed in 5 studies, but TNTs did not reveal a significant change in AHI (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TNTs may improve minimum oxygen saturation, ODI, RDI, and subjective\/quality\u2010of\u2010life measures. Allergic patients may have more improvement in OSA measures compared with nonallergic patients. Future studies are indicated to accurately determine the efficacy of TNTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22658","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T14:20:07Z","timestamp":1595773207000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Topical nasal treatment efficacy on adult obstructive sleep apnea severity: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-523X","authenticated-orcid":false,"given":"Dang\u2010Khoa","family":"Nguyen","sequence":"first","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Liang","sequence":"additional","affiliation":[{"name":"Otolaryngology Kaiser Permanente Northern California  Oakland 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