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Serum ECP level was measured within 1 week before surgery. Demographics and associated medical factors were analyzed with the surgical outcome, and nasal polyp histology was microscopically examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 58 patients met the inclusion criteria and underwent FESS. After at least a 1\u2010year follow\u2010up period, 9 patients had postoperative recurrence, with significantly higher serum ECP levels (<jats:italic>p<\/jats:italic> = 0.030). Receiver operating characteristic curve analysis showed the optimal cutoff level of serum ECP concentration for predicting the postoperative recurrence of nasal polyps was 21.8 \u00b5g\/L (<jats:italic>p<\/jats:italic> = 0.030). Regardless of atopy status and histology type, logistic regression analysis showed that a higher ECP level was the sole significant factor related to early postoperative recurrence of nasal polyps (odds ratio, 54.8; <jats:italic>p<\/jats:italic> = 0.014). Cox proportional hazard regression analysis revealed that the hazard ratio of CRSwNP patients with an ECP level of &gt;21.8 \u00b5g\/L resulting in early postoperative recurrence was 7.6 (<jats:italic>p<\/jats:italic> = 0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum ECP appears to be a feasible predictor for early postoperative recurrence of nasal polyps. CRSwNP patients with preoperative serum ECP levels of \u226521.8 \u00b5g\/L had an approximately 55\u2010fold increased risk of early recurrence. CRSwNP patients with higher preoperative serum ECP levels should be closely monitored within the first year after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22664","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T22:24:45Z","timestamp":1596752685000},"page":"766-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-9248","authenticated-orcid":false,"given":"Pin\u2010Ching","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Linkou Chang Gung Memorial Hospital  Taoyuan 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