{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:15Z","timestamp":1792949415803,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["#108\u2010N4249"],"award-info":[{"award-number":["#108\u2010N4249"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["#105\u20102314\u2010B\u2010002\u2010032"],"award-info":[{"award-number":["#105\u20102314\u2010B\u2010002\u2010032"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["#105\u20102314\u2010B\u2010002\u2010165"],"award-info":[{"award-number":["#105\u20102314\u2010B\u2010002\u2010165"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical characteristics of central\u2010compartment\u2010type chronic rhinosinusitis (CRS) in East Asian individuals are not clear. We sought to investigate the clinical features and the cytokine profiles of central\u2010compartment\u2010type CRS in our patient group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients diagnosed with bilateral CRS were recruited, and patients who had previously undergone sinus surgery and pansinusitis (Lund\u2010Mackay scores &gt;23) were excluded. Central\u2010compartment\u2010type CRS was defined by both endoscopic and radiological features. The symptoms, inhalant allergen sensitization status, endoscopic findings, and radiological assessments were recorded and compared between patients with central\u2010compartment\u2010type CRS and other types of CRS. We also examined the extent of tissue eosinophilia and specific cytokine protein levels (eosinophil cationic protein [ECP], myeloperoxidase [MPO], immunoglobulin E [IgE], interleukin [IL]\u20104, IL\u20105, and IL\u201013) in the sinonasal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Central\u2010compartment\u2010type CRS was found in 16 (23.9%) patients, and non\u2013central\u2010compartment\u2010type CRS was found in 51 (76.1%) patients. Hyposmia or anosmia as the major symptom was more common in the central\u2010compartment\u2010type CRS group. The numbers of eosinophils in tissue and serum were significantly higher in the central\u2010compartment\u2010type CRS patients. The presence of allergen sensitization was not significantly different between groups. The levels of IL\u20105 and IL\u201013 were increased in middle turbinate tissues of patients with central\u2010compartment\u2010type CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Central\u2010compartment\u2010type CRS was associated with hyposmia or anosmia, eosinophilic subtypes, and elevated levels of IL\u20105 and IL\u201013 in middle turbinate tissues but not necessarily correlated with allergic disease in our patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22759","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T22:27:36Z","timestamp":1612564056000},"page":"1064-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical characteristics and cytokine profiles of central\u2010compartment\u2010type chronic rhinosinusitis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3696-2661","authenticated-orcid":false,"given":"Yi\u2010Tsen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-1421","authenticated-orcid":false,"given":"Chun\u2010Kang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei 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