{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:09:23Z","timestamp":1774278563218,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:00:00Z","timestamp":1613260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is usually treated with corticosteroids, given their anti\u2010inflammatory effects. Unlike the nasal administration, the oral and ocular use of tretinoin, an immunoregulatory drug, is well established. Therefore, tretinoin was thought to act on nasal polyps, and possible adverse and\/or therapeutic effects were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A first\u2010in\u2010human open\u2010label trial was conducted enrolling patients with CRSwNP randomized into: a control group (CTR, n = 15), treated with budesonide for 24 weeks; and an intervention group (TRT, n = 15), who received budesonide and 0.1% tretinoin in the last 12 weeks. Primary endpoint included histopathological analysis and tissue immunoassay (Multiplex) for tumor necrosis factor \u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20101\u03b2, IL\u20104, IL\u20105, IL\u201013, and matrix metalloproteinase 9 (MMP\u20109) at 12 and 24 weeks. Secondary endpoints were: adverse events report, endoscopy (modified Lund\u2010Kennedy scoring system [LKS]), quality of life (22\u2010item Sino\u2010Nasal Outcome Test [SNOT\u201022]), and olfactory test (Connecticut Chemosensory Clinical Research Center) at baseline, at 12 weeks, and at 24 weeks, in addition to serum biochemistry and tomographic findings (Lund\u2010Mackay computed tomography [CT] staging system [LMS]) at baseline and 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TRT showed less microscopic edema (2\/13 [15.4%] vs 8\/13 [61.5%];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.044) as well as no increase in cytokines levels. All adverse events were categorized as \u201cgrade 1\u201d (asymptomatic; mild). The most interesting part of this study was the improvement in smell between baseline (T0) and week 24 (T2) in TRT only (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transnasal tretinoin associated with budesonide was safe and well tolerated, and it should be investigated as a treatment option for some CRSwNP endotypes. \u00a92021 ARSAAOA, LLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22778","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T12:57:49Z","timestamp":1613307469000},"page":"1187-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topical tretinoin in chronic rhinosinusitis with nasal polyps: a randomized clinical trial"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-1229","authenticated-orcid":false,"given":"Marcelo Augusto","family":"Antonio","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology University of Campinas (Unicamp)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-4234","authenticated-orcid":false,"given":"Fernando Augusto Lima","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Genomic Medicine Unicamp  Campinas S\u00e3o Paulo Brazil"},{"name":"Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds and Laboratory of Human and Medical Genetics, Postgraduate Program in Health Science University of S\u00e3o Francisco  Bragan\u00e7a Paulista S\u00e3o Paulo 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