{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:36:07Z","timestamp":1788834967572,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with asthma (CRS\u2010A) has a significant impact on patient morbidity and quality of life. Nevertheless, little is known about the natural history of endoscopic sinus surgery (ESS) in this cohort. The objective of this study was to evaluate revision rates of ESS in CRS\u2010A and identify risk factors associated with increased likelihood for revision surgery compared to those with CRS without asthma (CRS\u2010alone).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Utah Population Database was queried for patients age &gt;18 years with CRS who underwent at least 1 ESS between 1996 and 2018. Demographic information and history of ESS were collected and compared between CRS\u2010A and CRS\u2010alone using chi\u2010square tests for categorical variables and <jats:italic>t<\/jats:italic> tests for continuous variables. Risk factors for revision surgery were analyzed using Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33,090 patients (7693 CRS\u2010A and 25,397 CRS\u2010alone) were included in the final analysis. Mean follow up was 9.8 years in CRS\u2010A and 9.1 years in CRS\u2010alone (<jats:italic>p<\/jats:italic> &lt; 0.001). The revision rate among patients with CRS\u2010A (21.5%) was twice that of CRS\u2010alone (10.8%) (<jats:italic>p<\/jats:italic> &lt; 0.001). Among patients with CRS, a history of allergy (<jats:italic>p<\/jats:italic> &lt; 0.001), asthma (<jats:italic>p<\/jats:italic> &lt; 0.001), and nasal polyposis (<jats:italic>p<\/jats:italic> &lt; 0.001) was independently associated with increased risk of revision ESS. Patients with CRS\u2010A and nasal polyposis were 6 times more likely to require revision surgery than those with CRS\u2010alone (<jats:italic>p<\/jats:italic> &lt; 0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of revision ESS in CRS\u2010A was twice that of CRS\u2010alone; patients with CRS\u2010A and nasal polyposis were 6 times more likely to require revision than those with CRS\u2010alone. \u00a92021 ARSAAOA, LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22779","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T05:20:21Z","timestamp":1614230421000},"page":"1197-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Asthma increases long\u2010term revision rates of endoscopic sinus surgery in chronic rhinosinusitis with and without nasal polyposis"],"prefix":"10.1002","volume":"11","author":[{"given":"Amarbir S.","family":"Gill","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7026-5819","authenticated-orcid":false,"given":"Kristine A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Manitoba  Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong","family":"Meeks","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource, Huntsman Cancer Institute University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen M.","family":"Oakley","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource, Huntsman Cancer Institute University of Utah  Salt Lake City UT"},{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"LeClair","sequence":"additional","affiliation":[{"name":"Department of Pulmonology\/Critical Care Medicine University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Howe","sequence":"additional","affiliation":[{"name":"Department of Pulmonology\/Critical Care Medicine University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-9144","authenticated-orcid":false,"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Deaths: final data for 2010","volume":"61","author":"Murphy SL","year":"2013","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_7_3_1","first-page":"53","article-title":"Asthma and chronic rhinosinusitis: diagnosis and medical management","volume":"7","author":"Massoth L","year":"2019","journal-title":"Med Sci (Basel)"},{"key":"e_1_2_7_4_1","unstructured":"Centers for Disease Control and Prevention (CDC).Most recent national asthma data.Atlanta GA:CDC;2018.https:\/\/www.cdc.gov\/asthma\/most_recent_national_asthma_data.htm. 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