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This study establishes the factor structure, responsiveness, and convergent validity of the CRS\u2010PRO following endoscopic sinus surgery (ESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Northwestern CRS Subject Registry patients had pre\u2010ESS, 3\u2010month (n = 111; CRS without nasal polyps [CRSsNP] = 60, CRS with nasal polyps [CRSwNP] = 51), and 6\u2010month (n = 86; CRSsNP = 47, CRSwNP = 39) post\u2010ESS assessments where patients completed the CRS\u2010PRO, 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022), and four Patient\u2010Reported Outcomes Measurement (PROM) Information System (PROMIS) short forms (general health measures). Patients had pre\u2010ESS objective testing (endoscopic and radiographic assessment). Factor analysis was conducted using principal axis factoring with varimax rotation on the baseline CRS\u2010PRO. The clinically important difference (CID) was estimated using both distribution\u2010based and anchor\u2010based methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factor analysis found the CRS\u2010PRO comprised the \u201crhino\u2010psychologic,\u201d \u201cfacial discomfort,\u201d and \u201ccough\u201d factors, which were responsive to ESS and correlated with the other PROMs. The changes observed in the CRS\u2010PRO at 3 months had strong correlation with the corresponding changes in SNOT\u201022 (<jats:italic>r<\/jats:italic> = 0.792, <jats:italic>p<\/jats:italic> &lt; 0.0001) and moderate correlations with changes in PROMIS fatigue and sleep domains. These changes had a very large effect size (Cohen's d 1.44) comparable to the longer SNOT\u201022 (Cohen's d 1.41) with slightly larger effect sizes observed in CRSwNP compared to CRSsNP patients. Similar convergent validity and responsiveness were observed in the 6\u2010month data. The CRS\u2010PRO CID was estimated to be between 5.0 and 7.5 (midpoint 6.0) using distribution\u2010based and anchor\u2010based methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates the validity and responsiveness of the CRS\u2010PRO in subjects receiving ESS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22782","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T06:47:00Z","timestamp":1615963620000},"page":"1308-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Responsiveness and convergent validity of the chronic rhinosinusitis patient\u2010reported outcome (CRS\u2010PRO) measure in CRS patients undergoing endoscopic sinus surgery"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-7192","authenticated-orcid":false,"given":"Katherine 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