{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:04:22Z","timestamp":1784282662105,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The accuracy of diagnoses of acute invasive fungal rhinosinusitis (AIFRS) based on frozen sections has been questioned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, SCOPUS, and Google Scholar were used for data sources. True\u2010positive, true\u2010negative, false\u2010positive, and false\u2010negative data were extracted for each study. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS\u20102) Tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine prospective and retrospective studies were included. The diagnostic odds ratio of intraoperative frozen section in AIFRS was 124.4717 (95% confidence interval [CI], 75.5168\u2013205.1623). The area under the summary receiver operating characteristic curve was 0.906. The sensitivity, specificity, and positive predictive value were 0.8337 (95% CI, 0.7962\u20130.8655), 0.9858 (95% CI, 0.9330\u20130.9971), and 0.9822 (95% CI, 0.8905\u20130.9973), respectively. The correlation between sensitivity and the false\u2010positive rate was 0.437, indicating a lack of heterogeneity. In subgroup analysis, the \u201cper patient\u201d subgroup tended to show higher diagnostic accuracy than the \u201cper specimen\u201d subgroup. Regarding fungal species, the frozen biopsy of aspergillus showed higher sensitivity than that of mucor (0.8103\u00a0vs. 0.7544).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive frozen sections are reliable and facilitate early intervention in AIFRS. Collecting multiple specimens during surgery will decrease the rate of false\u2010negative results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22797","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T18:06:20Z","timestamp":1616781980000},"page":"1347-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Usefulness of intraoperative frozen section for diagnosing acute invasive fungal rhinosinusitis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Do Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-7820","authenticated-orcid":false,"given":"Se Hwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine, Bucheon St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817697279"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Frozen sectioning to diagnose invasive fungal sinusitis","volume":"157","author":"Hennessy MA","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3938-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21918"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.018"},{"key":"e_1_2_6_8_1","article-title":"Accuracy of intraoperative frozen section in detection of acute invasive fungal rhinosinusitis","author":"Alkhateb R","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0031302031000123173"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818770615"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0965-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0226"},{"key":"e_1_2_6_14_1","first-page":"619\u2010627","article-title":"Clinical application of a digital method to improve the accuracy of color perception in toluidine blue stained oral mucosal lesions","volume":"44","author":"Guneri P","year":"2013","journal-title":"Quintessence Int"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181dde8fc"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111001289"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70238-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13613"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25899"}],"container-title":["International Forum of Allergy &amp; 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