{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:57:57Z","timestamp":1774533477104,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Management of sinonasal malignancy (SNM) often includes surgical resection as part of the multimodality treatment. Treatment\u2010related surgical morbidity can occur, yet risk factors associated with complications in this population have not been sufficiently investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with histologically confirmed SNM whose primary treatment included surgical resection were prospectively enrolled into an observational, multi\u2010institutional cohort study from 2015 to 2020. Sociodemographic, disease, and treatment data were collected. Complications assessed included cerebrospinal fluid leak, orbital injury, intracranial injury, diplopia, meningitis, osteoradionecrosis, hospitalization for neutropenia, and subsequent chronic rhinosinusitis. The surgical approach was categorized as endoscopic resection (ER) or open\/combined resection (O\/CR). Associations between factors and complications were analyzed using Student's t test, Fisher's exact test, and logistic regression modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 142 patients met the inclusion criteria. Twenty\u2010three subjects had at least 1 complication (16.2%). On unadjusted analysis, adjuvant radiation therapy was associated with developing a complication (91.3% vs 65.5%, <jats:italic>p<\/jats:italic> = 0.013). Compared with the ER group (n = 98), the O\/CR group (n = 44) had a greater percentage of higher T\u2010stage lesions (<jats:italic>p<\/jats:italic> = 0.004) and more frequently received adjuvant radiation (84.1% vs 64.4%, <jats:italic>p<\/jats:italic> = 0.017) and chemotherapy (50.0% vs 30.6%, <jats:italic>p<\/jats:italic> = 0.038). Complication rates were similar between the ER and O\/CR groups without controlling for other factors. Regression analysis that retained certain factors showed O\/CR was associated with increased odds of experiencing a complication (odds ratio, 3.34; 95% confidence interval, 1.06\u201011.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prospective, multicenter evaluation of SNM treatment outcomes is feasible. Undergoing O\/CR was associated with increased odds of developing a complication after accounting for radiation therapy. Further studies are warranted to build upon these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22833","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T10:18:32Z","timestamp":1624789112000},"page":"1617-1625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-5442","authenticated-orcid":false,"given":"Daniel M.","family":"Beswick","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher H.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Arizona  Tucson AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Humphreys DO","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington  Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Getz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davis M.","family":"Aasen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed M.","family":"Abuzeid","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington  Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Arizona  Tucson AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Kaizer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics University of Colorado  Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd T.","family":"Kindgom","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Kohanski","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Nabavizadeh","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakar V.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-982X","authenticated-orcid":false,"given":"Zara M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay R.","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck 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