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The current wholesale acquisition costs for biologics are quite high. Widespread, prolonged use of these medications may create a large burden to our healthcare system. Cost\u2010effectiveness analyses, particularly for specific patient cohorts, are needed to determine appropriate use of these medications. The ethics of patient preference of various treatment options, counseling regarding side effect profiles, and healthcare economics also need to be addressed.<\/jats:p>","DOI":"10.1002\/alr.22864","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T06:44:22Z","timestamp":1626072262000},"page":"1524-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biologics for chronic rhinosinusitis with nasal polyps: Economics and ethics"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-7611","authenticated-orcid":false,"given":"Lauren T.","family":"Roland","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of California, San Francisco  San Francisco California 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