{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:23:29Z","timestamp":1747146209914,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Opioid abuse is a public health crisis and the perioperative period can be a time of first opioid exposure. Little is known about postoperative pain management after endoscopic skull base surgery (ESBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This investigation was a single\u2010institution, longitudinal, prospective cohort study of adult patients undergoing ESBS between November 2019 and March 2020. Participants completed preoperative questionnaires and were contacted every 48\u00a0hours postoperatively to quantify pain and opioid consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33 patients were enrolled and 28 of 33 patients (85%) underwent ESBS for sellar pathology. Mean total morphine milligram equivalents (MME) consumed was 381.9 \u00b1 476.0. History of a headache disorder (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025) and previous opioid use within 60 days preoperatively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were significantly associated with greater opioid use. Mean duration of opioid use was 6.7 \u00b1 5.1 (range, 0\u201020) days. Headache disorder (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), depression (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), anxiety (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), age \u226446 years (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), and previous opioid use (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) were all associated with longer mean opioid use. Patients with headache disorder also reported higher mean postoperative pain scores. Fewer than half of the participants required opioids by postoperative day 8. Prescription of nonsteroidal anti\u2010inflammatory drugs at discharge was significantly associated with less outpatient opioid use (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032). At 2\u2010month follow\u2010up, 37% of patients reported keeping excess opioids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After ESBS, greater total opioid use was significantly associated with history of headaches and previous opioid use within 60 days. Overall, opioid use declined among all patients in the postoperative period, but several factors may contribute to longer duration of use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22871","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:57:01Z","timestamp":1627300621000},"page":"160-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Opioid use after endoscopic skull base surgery: A descriptive, prospective, longitudinal cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-8183","authenticated-orcid":false,"given":"Ryan A.","family":"Rimmer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Pailet","sequence":"additional","affiliation":[{"name":"School of Medicine Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-4008","authenticated-orcid":false,"given":"Nyssa Fox","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in St. Louis  St. Louis MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara Y.","family":"Detwiller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7083","authenticated-orcid":false,"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aclan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Cetas","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Geltzeiler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1714529"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031914-122957"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.3\/tcicero"},{"volume-title":"White House ONDCP (Off. 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