{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:35:21Z","timestamp":1780590921004,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical steroids are first\u2010line treatment for chronic rhinosinusitis (CRS), but fail to provide adequate symptom control for all patients. Designed for medical treatment failures, LYR\u2010210 is an implantable matrix that locally elutes mometasone furoate to inflamed sinonasal tissue for up to 24 weeks in CRS patients. In an open\u2010label phase 1 study, LYR\u2010210 demonstrated clinically relevant improvement in the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022). Safety and efficacy of LYR\u2010210 in CRS were evaluated in the LANTERN Phase 2 study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven surgically naive adult CRS patients who were inadequately controlled by previous medical management and seeking an alternative treatment enrolled in a multicenter, blinded, controlled, dose\u2010ranging study. Patients had moderate\u2010to\u2010severe disease based on SNOT\u201022 and composite 7\u2010day average scores of the 4 cardinal CRS symptoms (4CS), with diagnosis confirmed by nasal endoscopy and magnetic resonance imaging. Patients were randomized (1:1:1) to saline irrigation\u2013only control or bilateral in\u2010office administration of LYR\u2010210 (2500 \u03bcg) or LYR\u2010210 (7500 \u03bcg). Safety and efficacy were evaluated over 24 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both LYR\u2010210 doses were safe and well\u2010tolerated over the 24\u2010week treatment period. LYR\u2010210 demonstrated rapid and durable dose\u2010dependent symptom improvement based on 4CS and SNOT\u201022, with LYR\u2010210 (7500 \u03bcg) achieving statistical significance as early as 8 weeks and out to 24 weeks compared with control. LYR\u2010210 (7500 \u03bcg) reduced rescue treatment use and radiographic ethmoid opacification at week 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LYR\u2010210 is the first implantable sinonasal treatment to achieve up to 24 weeks of benefit from a single administration in surgically naive CRS patients with and without nasal polyps.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22883","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T19:56:21Z","timestamp":1631908581000},"page":"147-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study"],"prefix":"10.1002","volume":"12","author":[{"given":"Anders","family":"Cervin","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research Royal Brisbane &amp; Women's Hospital Campus  Herston QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Rimmer","sequence":"additional","affiliation":[{"name":"Monash Health and Department of Surgery Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Centrum Medyczne, AllMed  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogen","family":"Abelak","sequence":"additional","affiliation":[{"name":"VistaMed Sp. z o.o.  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Brayton","sequence":"additional","affiliation":[{"name":"Lyra Therapeutics, Inc  Watertown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Kuang","sequence":"additional","affiliation":[{"name":"Lyra Therapeutics, Inc  Watertown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1500ED"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0715-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.009"},{"issue":"29","key":"e_1_2_7_6_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_7_8_1","first-page":"405","article-title":"Ventilation and aerosolized drug delivery to the paranasal sinuses using pulsating airflow\u2014a preliminary study","volume":"47","author":"Moeller W","year":"2009","journal-title":"Rhinology"},{"issue":"1","key":"e_1_2_7_9_1","first-page":"S49","article-title":"Nasal spray adherence after sinus surgery: problems and predictors","volume":"41","author":"Nabi S","year":"2012","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2012.3.0027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199310000-00007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22288"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21694_c"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894041130S506"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813513881"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.072"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730040-00004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22084"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000062554.74615.4C"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.03.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22269"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26157"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20192720"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13177"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-012-0003-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(02)02529-1"}],"container-title":["International Forum of Allergy &amp; 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