{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:13:12Z","timestamp":1791807192314,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, limited data exist as to long\u2010term disease\u2010specific outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). In this report, we present outcomes data collected over 5 years in a large prospective cohort of patients who underwent surgical treatment for CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who completed the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) before ESS were asked to complete the same survey at yearly intervals for 5 years thereafter. The impact of patients\u2019 demographics and clinical characteristics on clinical outcome was measured using mixed effects modeling for univariate and multivariable analysis. Multivariable logistic regression threshold analyses were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 925 patients enrolled in the study, the SNOT\u201022 was completed after ESS by 641 patients (69.3%) at 1 year and 338 patients (36.5%) at 5 years. The mean preoperative SNOT\u201022 score of 48.5 (standard error [SE], 0.69) improved at all subsequent yearly time\u2010points, including 5 years (mean,\u00a025.8; SE, 1.08; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). SNOT\u201022 scores over time were impacted by nasal polyps (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), environmental allergies (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), diabetes (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032), and preoperative Lund\u2010Mackay score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endoscopic sinus surgery appears to be effective at improving the quality of life of patients with CRS for both the short and long term. The successful outcome of such surgery, however, is influenced by a variety of clinical factors, which should be taken into account by clinicians who are considering surgical treatment of CRS for select patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22886","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:00:30Z","timestamp":1631469630000},"page":"257-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Endoscopic sinus surgery for chronic rhinosinusitis: 22\u2010item Sino\u2010Nasal Outcome Test 5\u2010year results"],"prefix":"10.1002","volume":"12","author":[{"given":"Jonathan C.","family":"Simmonds","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear  Boston MA USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Harvard Medical School  Boston MA 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