{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:19:59Z","timestamp":1790194799422,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>The 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) and 12\u2010item Patient Reported Outcomes in Chronic Rhinosinusitis (CRS\u2010PRO) instrument are validated patient\u2010reported outcomes measures in CRS. In this study we assess the correlation of these with type 2 (T2) biomarkers before and after endoscopic sinus surgery (ESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Middle meatal mucus data were collected and the SNOT\u201022 and CRS\u2010PRO were administered to 123 patients (71 CRS without nasal polyps [CRSsNP], 52 CRS with nasal polyps [CRSwNP]) with CRS before and 6 to 12 months after undergoing ESS. Interleukin (IL)\u20104, IL\u20105, IL\u201013, and eosinophilic cationic protein (ECP) were measured using a multiplexed bead assay and enzyme\u2010linked immunoassay. Pre\u2010 and post\u2010ESS SNOT\u201022 and CRS\u2010PRO were compared with T2 biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before ESS neither PROM correlated with any biomarker. After ESS, CRS\u2010PRO showed a correlation with 2 mediators (IL\u20105 and IL\u201013: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012 and 0.003, respectively) compared with none for the SNOT\u201022. For CRSwNP patients, pre\u2010ESS CRS\u2010PRO and SNOT\u201022 correlated with IL\u20104 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 for both). However, after ESS, CRS\u2010PRO correlated with 3 biomarkers (IL\u20105, IL\u201013, and ECP: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, 0.024, and 0.04, respectively) and SNOT\u201022 with 2 biomarkers (IL\u20105 and IL\u201013: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038 and 0.02, respectively). There were no significant relationships between any of the T2 biomarkers pre\u2010 or post\u2010ESS among patients with CRSsNP. Exploratory analyses of the subdomains showed the SNOT\u201022 rhinologic and CRS\u2010PRO rhinopsychologic subdomains correlated better with the T2 biomarkers. On individual item analysis, IL\u201013 correlated significantly post\u2010ESS with 8 of 12 items on the CRS\u2010PRO vs 6 of 22 items on the SNOT\u201022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CRS\u2010PRO total score showed a significant correlation with T2 biomarkers especially when assessed post\u2010ESS and among CRSwNP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23002","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T17:49:17Z","timestamp":1648835357000},"page":"1377-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["CRS\u2010PRO and SNOT\u201022 correlations with type 2 inflammatory mediators in chronic rhinosinusitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-2744","authenticated-orcid":false,"given":"Samuel 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