{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:00:54Z","timestamp":1774674054103,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mometasone\u2010eluting stents (MES) have demonstrated improvement in short\u2010term endoscopic outcomes and reduce short\u2010 to medium\u2010term rescue interventions. Their effect on the local inflammatory environment, longer\u2010term patient\u2010reported outcomes, and radiographic severity have not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Middle meatal mucus and validated measures of disease severity were collected before and 6 to 12 months after endoscopic surgery in 52 patients with chronic rhinosinusitis with nasal polyps (CRSwNPs). Operative findings, type 2 mediator concentrations, intraoperative variables, and disease severity measures were compared between those who did and those who did not receive intraoperative frontal MES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 52 patients with CRSwNPs were studied; 33 received frontal MES and were compared with 19 who did not. Pre\u2013endoscopic sinus surgery (ESS) middle meatus (MM) interleukin (IL) 13 and eosinophil cationic protein (ECP) were higher in the stented group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), but pre\u2010ESS clinical measures of disease severity were similar as were surgical extent and post\u2010ESS medical management. Intraoperative eosinophilic mucin was more frequent in the stented group (58% vs 11%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). IL\u20105 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and IL\u201013 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) decreased post\u2010ESS in the stented group, but this was not observed in the nonstented group. Post\u2010ESS IL\u20104 and IL\u201013 were higher in the nonstented vs stented group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although patients who received intraoperative frontal MES had significantly higher pre\u2010ESS MM IL\u201013 and ECP, patients who received frontal MES had lower concentrations of IL\u20104 and IL\u201013 than those who did not at a median of 8 months post\u2010ESS. However, these changes did not correspond to significantly different measures of symptomatic or radiographic disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23005","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:30:36Z","timestamp":1648798236000},"page":"1330-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of intraoperative frontal sinus mometasone\u2010eluting stents decreased interleukin 5 and interleukin 13 in patients with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-646X","authenticated-orcid":false,"given":"Alexander L.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Northwestern University Feinberg School of Medicine  Chicago Illinois 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