{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:45:03Z","timestamp":1787921103121,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression\u2010free survival (PFS), and distant metastasis\u2013free survival (DMFS) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 143 included patients, the 5\u2010year OS was 82.3% and the 5\u2010year PFS was 51.6%; 5\u2010year OS and PFS have improved in the modern era (2005\u2013present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Higher Hyams grade had a negative effect on PFS and DMFS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Positive margin status had a negative effect on PFS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Orbital invasion demonstrated worsening OS (hazard ratio, 3.1; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). On multivariable analysis, high Hyams grade (3 or 4), high mKadish stage (C+D), and increasing age were independent negative prognostic factors for OS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). High Hyams grade (3+4), high mKadish stage (C+D), age, and positive margin status were independent negative prognostic factors for PFS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). High Hyams grade (3+4) was an independent negative prognostic factor for DMFS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with low Hyams grade and mKadish stage have favorable 5\u2010year OS, PFS, and DMFS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23007","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T18:20:09Z","timestamp":1649269209000},"page":"1457-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long\u2010term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Ryan A.","family":"McMillan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mayo Clinic School of Medicine  Rochester Minnesota 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