{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:52:24Z","timestamp":1790016744127,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82025010"],"award-info":[{"award-number":["82025010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071022"],"award-info":[{"award-number":["82071022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870698"],"award-info":[{"award-number":["81870698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a refractory clinical phenotype with a high symptom burden and relapse rate. Steroid\u2010eluting stents are safe and effective for reducing polyp size, symptom burden, and the need for revision sinus surgery. In this study we aimed to evaluate the efficacy and safety of steroid\u2010eluting stent implantation on the surgical outcomes of patients with ECRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter, randomized, intrapatient\u2010controlled trial recruited patients 18 to 65 years of age with ECRSwNP who required surgery. Ninety\u2010eight patients were enrolled and randomly implanted with absorbable steroid\u2010eluting stents containing mometasone furoate in one sinus at the end of surgery. All patients received standard postoperative care and follow\u2010up. The primary outcome was the Lund\u2010Kennedy endoscopic score within 12\u00a0weeks postsurgery. Secondary outcomes included nasal symptoms scores, nasal resistance, acoustic rhinometry, nasal nitric oxide levels, 3\u2010dimensional volumetric computed tomography scores, and eosinophil counts in the ethmoid mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010five patients completed the trial. At postoperative weeks 4, 8, and 12, the Lund\u2010Kennedy scores were significantly lower on the treatment side than on the control side (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Compared with the treatment side, the control side exhibited higher tissue eosinophilia at week 4 and higher volumetric, nasal obstruction, and total nasal symptom scores at postoperative week 8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001, respectively). No adrenal cortical suppression or serious side effects were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Steroid\u2010eluting stents reduce postoperative sinus mucosal edema, and eosinophilic inflammation, with persistent effects after stent disintegration, and are a good supplementary postsurgical treatment in patients with ECRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.23085","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T02:44:51Z","timestamp":1662777891000},"page":"899-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010term postoperative efficacy of steroid\u2010eluting stents for eosinophilic chronic rhinosinusitis with nasal polyps: A randomized clinical trial"],"prefix":"10.1002","volume":"13","author":[{"given":"Chengshuo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing 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