{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:50:35Z","timestamp":1789753835350,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis (AR) is characterized by distinct clinical heterogeneity and allergic sensitization patterns. We aimed to quantify rhinitis symptoms in patients with self\u2010reported allergic rhinitis according to the potential sensitization patterns for relevant allergens in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used latent class analysis (LCA; a subset of structural equation modeling) to independently cluster patients into different patterns of atopic sensitization in an unsupervised manner, based on specific immunoglobulin E tests. AR symptom severity was assessed by the visual analogue scale. We evaluated the association between the severity of AR and the allergen sensitization patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LCA revealed four phenotypes of atopic sensitization among 967 patients with self\u2010report AR. We labeled latent classes as: Class 1, weed pollens and indoor sensitization (<jats:italic>n<\/jats:italic> = 74 [7.7%]); Class 2, weed pollen with low indoor sensitization (<jats:italic>n<\/jats:italic> = 275 [28.4%]); Class 3, low or no sensitization (<jats:italic>n<\/jats:italic> = 350 [36.2%]); and Class 4, house dust mite\u2010dominated sensitization (<jats:italic>n<\/jats:italic> = 268 [27.7%]). AR was more severe in Class 2 compared to the other 3 classes, indicating that upper respiratory symptoms are more severe among patients with isolated seasonal rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have identified four sensitization patterns in patients with self\u2010reported AR, which were associated with different clinical symptoms and comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23098","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T12:09:56Z","timestamp":1666613396000},"page":"1007-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Rhinitis symptom in patients with self\u2010reported allergic rhinitis is influenced by sensitization pattern: A cross\u2010sectional study of China"],"prefix":"10.1002","volume":"13","author":[{"given":"Liting","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology Department of Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Centre Institute of Translational Medicine Faculty of Health Sciences University of Macau  Taipa Macau China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Taipa Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Department of Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Department of Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Allergy State Grid Beijing Electric Power Hospital Capital Medical University Electric Power Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boai Hospital of Zhongshan City  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Allergy and Precision Medicine Chengdu Institute of Respiratory Health the Third People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Weifang Weien Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Dong","sequence":"additional","affiliation":[{"name":"General Hospital Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Xijing Hospital the Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Maternity and Child Care Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Yinchuan Maternal and Child Health Care Hospital  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicun","family":"Hu","sequence":"additional","affiliation":[{"name":"The Second People's 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