{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T12:30:01Z","timestamp":1748953801602},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal lymphoma (SL) is a heterogeneous, underrecognized neoplastic disorder with limited outcomes data. We sought to better define outcomes by subtype and treatment at 2 referral centers over the past 2 decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographics, clinicopathologic data, and treatment outcomes for patients treated for SL were queried from January 1, 2000 to December 31, 2021 at 2 tertiary academic medical centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients were included, with an average age at diagnosis of 63.4\u00a0\u00b1\u00a015 years. There were 34 females (40.5%). The majority of patients had an Eastern Cooperative Oncology Group (ECOG) score of &lt;2 (76.2%) and the most common presenting symptom was facial swelling\/pain (26.2%). The most common primary site was the nasal cavity (36.9%). Diffuse large B\u2010cell lymphoma was the most common subtype (46.4%), followed by extranodal NK\/T\u2010cell lymphoma (17.9%). Chemotherapy was the most common treatment strategy (n\u00a0=\u00a059, 70.2%), followed by radiation therapy (n\u00a0=\u00a035, 41.7%) and immunotherapy (n\u00a0=\u00a024, 28.6%). Disease\u2010specific survival rates at 1, 5, and 10 years were 85.7%, 73.6%, and 58.6%, respectively. Eighteen patients (21.4%) developed recurrence. On multivariate analysis, higher ECOG score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and history of head and neck radiation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.048) were associated with worse survival. Younger age was associated with greater risk of recurrence (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022) and male sex was associated with more treatment side effects (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the largest multi\u2010institutional analysis of SL characteristics and outcomes. Our work suggests that, although disease control in the first 5 years is reasonable, 10\u2010year outcomes remain challenging. Further studies are needed to investigate new treatment paradigms and risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23102","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T14:30:14Z","timestamp":1669473014000},"page":"1492-1502","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary sinonasal lymphoma: A multi\u2010institutional experience of clinical presentation, treatment, and outcomes"],"prefix":"10.1002","volume":"13","author":[{"given":"Jacob G.","family":"Eide","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rijul S.","family":"Kshirsagar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Pennsylvania  Philadelphia 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