{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:45:25Z","timestamp":1787676325717,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007631","name":"Chungnam National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007631","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inotodiol has been proven to have antitumor, antiviral, anti\u2010inflammatory, and antiallergic properties. This study investigated the immunomodulatory capability of inotodiol in allergic rhinitis (AR) mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty BALB\/c mice were divided into four groups, 10 mice each: control (CON), AR with phosphate\u2010buffered saline (PBS) treatment (AR), inotodiol treatment (AR+Ino), and dexamethasone treatment (AR+Dex). Episodes of sneezing and nose rubbing were counted. Cytokines in nasal lavage fluid (NLF) and immunoglobulin in blood serum were measured. Nasal mucosae from each group were used for protein, reverse transcriptase\u2013polymerase chain reaction (RT\u2010PCR), and histological analyses. Splenocytes were cultured for evaluation of cytokine production in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptoms of rubbing and sneezing improved in the group of AR+Ino and AR+Dex than in the AR. NLF in the AR+Ino and AR+Dex also showed a significant decrease in interleukin (IL)\u20105, IL\u201010, and IL\u201013 compared to the AR. In addition, the number of eosinophils, goblet cells, and mast cells were notably lower in the nasal mucosae of the AR+Ino and AR+Dex. IL\u20104 and IL\u201017A in the AR+Ino and AR+Dex groups were decreased compared to the AR. Chemokines related to mast cell degradation were also decreased in the AR+Ino and AR+Dex groups. Total immunoglobulin (Ig)E, specific IgE and ovalbumin (OVA)\u2010specific IgG1, and histamine levels were also significantly lower in the AR+Ino and AR+Dex groups. IL\u201010 and IL\u201013 were notably increased in the splenocytes of the AR after OVA stimulation, whereas the other groups showed no change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate inotodiol can help suppress allergic responses by immunomodulation activities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23121","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T08:54:21Z","timestamp":1672304061000},"page":"1603-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inotodiol suppresses allergic inflammation in allergic rhinitis mice"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-3345","authenticated-orcid":false,"given":"Jaein","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University College of Medicine  Daejeon South Korea"},{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Ra","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University College of Medicine  Daejeon South Korea"},{"name":"Department of Medical Science Chungnam National University College of Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-536X","authenticated-orcid":false,"given":"Soo\u2010kyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University College of Medicine  Daejeon South Korea"},{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University College of Medicine  Daejeon South Korea"},{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungnam National University College of Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Tae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Chungnam National University  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University College of Medicine  Daejeon South Korea"},{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungnam National University Hospital  Daejeon South Korea"},{"name":"Department of Medical Science Chungnam National University College of Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01367.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.955"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2014.7.4.241"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/805841"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000204"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.12.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6384"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.09.064"},{"issue":"5","key":"e_1_2_8_12_1","first-page":"2691","article-title":"Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase\u20103\u2010dependent apoptosis","volume":"28","author":"Nomura M","year":"2008","journal-title":"Anticancer Res"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977528"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572-5995(00)80024-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106244"},{"issue":"8","key":"e_1_2_8_16_1","first-page":"1067","article-title":"Protective effects and mechanism of Inonotus obliquus on asthmatic mice","volume":"36","author":"Yan G","year":"2011","journal-title":"China J Chinese Materia Med"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.025"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.650841"},{"issue":"8","key":"e_1_2_8_19_1","first-page":"2533","article-title":"The utility of measuring urinary metabolites of mast cell mediators in systemic mastocytosis and mast cell activation syndrome","volume":"8","author":"Butterfield J","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00494.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22510"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.3.638"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13091441"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152957"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN107655"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154704"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.23121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:23:33Z","timestamp":1692789813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.23121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/alr.23121"],"URL":"https:\/\/doi.org\/10.1002\/alr.23121","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}