{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:13:23Z","timestamp":1785194003240,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is accompanied by burdensome comorbid conditions. Understanding the relative timing of the onset of these conditions could inform disease prevention, detection, and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between CRS and new\u2010onset and prevalent asthma, noncystic fibrosis bronchiectasis (NCFBE), chronic obstructive pulmonary disease (COPD), gastroesophageal reflux disease (GERD), and obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cohort study among primary care patients using a detailed medical and symptom questionnaire in 2014 and again in 2020. We used questionnaire and electronic health record (EHR) data to determine CRS status: CRS<jats:sub>SE<\/jats:sub> (moderate to severe symptoms with EHR evidence), CRS<jats:sub>E<\/jats:sub> (limited symptoms with EHR evidence), CRS<jats:sub>S<\/jats:sub> (moderate to severe symptoms without EHR evidence), CRS<jats:sub>neg<\/jats:sub> (limited symptoms and no EHR evidence; reference). We evaluated the association between CRS status and new\u2010onset and prevalent disease using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 7847 and 4445 respondents to the 2014 and 2020 questionnaires, respectively. CRS<jats:sub>SE<\/jats:sub> (vs CRS<jats:sub>neg<\/jats:sub>) was associated with increased odds of new\u2010onset asthma (OR, 1.74 [CI, 1.09\u20132.77), NCFBE (OR, 1.87 [CI, 1.12\u20133.13]), COPD (OR, 1.73 [CI, 1.14\u20132.68]), GERD (OR, 1.95 [CI, 1.61\u20132.35]), and OSA (OR, 1.91 [CI, 1.39\u20132.62]). Similarly, increased odds were observed for associations with the prevalence of these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23136","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T08:15:52Z","timestamp":1675930552000},"page":"1715-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of new\u2010onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-2171","authenticated-orcid":false,"given":"Annemarie G.","family":"Hirsch","sequence":"first","affiliation":[{"name":"Department of Population Health Sciences Geisinger  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