{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:30:58Z","timestamp":1791469858811,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC005805"],"award-info":[{"award-number":["R01 DC005805"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poor air quality increases the risk of developing chronic rhinosinusitis (CRS) and other airway diseases. However, there are limited data on air pollutants and CRS\u2010specific disease severity. We assessed the impact of air pollutants on sinonasal\u2010specific and general quality\u2010of\u2010life (QOL) measures in a multi\u2010institutional cohort of patients with CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with CRS were prospectively enrolled in a cross\u2010sectional study and self\u2010selected continued appropriate medical therapy or endoscopic sinus surgery (ESS). The 22\u2010item SinoNasal Outcome Test (SNOT\u201022) and Medical Outcomes Study Questionnaire Short\u2010Form 6\u2010D (SF\u20106D) health utility value scores were recorded. Patient exposure to air pollutants was determined using residence zip codes. Unadjusted group differences were compared, and correlation coefficients were evaluated to identify the magnitude of bivariate association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 486 patients were enrolled and followed for a mean of 6.9 (standard deviation [SD]\u00a0\u00b1\u00a02.3) months. Pollutant exposure did not significantly correlate with baseline SNOT\u201022 or SF\u20106D scores. Revision ESS was associated with higher median fine particulate matter (PM2.5; \u0394\u00a0=\u00a00.12, [95% confidence interval {CI}: 0.003, 0.234]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) compared with primary surgery. PM2.5, PM10, and nitrogen dioxide concentrations (\u03bcg\/m<jats:sup>3<\/jats:sup>) did not correlate with change in total SNOT\u201022 or SF\u20106D scores after treatment. Nevertheless, sulfur dioxide (SNOT\u201022: <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u20130.121 [95% CI: \u20130.210, \u20130.030]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007; SF\u20106D: <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.095 [95% CI: 0.002, 0.186]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and carbon monoxide (SNOT\u201022: <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u20100.141 [95% CI: \u20130.230, 0.050]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) exposure did correlate with these outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Air pollutants may contribute, at least in part, to disease severity in CRS; future investigation is needed to further elucidate the nature of this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23250","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:38:45Z","timestamp":1691577525000},"page":"755-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?"],"prefix":"10.1002","volume":"14","author":[{"given":"Robert","family":"Hagedorn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-8550","authenticated-orcid":false,"given":"Benton","family":"Tullis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Stockard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C","family":"Mace","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery\/Oregon Sinus Center Department of Otolaryngology \u2013 Head and Neck Surgery Oregon Health &amp; Science University (OHSU)  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay R","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Indiana  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-5442","authenticated-orcid":false,"given":"Daniel M","family":"Beswick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7083","authenticated-orcid":false,"given":"Timothy L","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery\/Oregon Sinus Center Department of Otolaryngology \u2013 Head and Neck Surgery Oregon Health &amp; 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