{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:39:21Z","timestamp":1791689961517,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acoustic resonance therapy (ART) is a novel vibrational treatment that delivers patient\u2010specific resonant frequency acoustic energy to the sinonasal cavities. In a pilot study, ART was effective for the acute treatment of nasal congestion. We conducted a sham\u2010controlled randomized trial to validate the efficacy of ART when administered daily for 2\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 52 adult patients were enrolled in a multi\u2010center, randomized, double\u2010blinded, sham\u2010controlled, interventional study evaluating ART administered by a vibrational headband. Patients received either active treatment or a non\u2010therapeutic sham treatment twice daily over 2\u00a0weeks. Clinical endpoints were the average change in nasal congestion sub\u2010score of the Total Nasal Symptom Score (TNSS) and the average change in composite TNSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ART resulted in a significantly greater mean change in the nasal congestion sub\u2010score compared to sham (\u22120.87 [95% confidence interval [CI] \u22121.11, \u22120.62] vs. \u22120.44 [95% CI \u22120.64, \u22120.23],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008). ART also resulted in a significantly greater reduction in the composite TNSS versus sham, (\u22122.85 [95% CI \u22123.85, \u22121.85], vs. \u22121.32 [95% CI \u22122.27, \u22120.36],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.027). The response rate, determined by a nasal congestion sub\u2010score minimal clinically important difference of 0.23, was 80.8% for ART and 46.2% for sham, with an adjusted risk ratio of 1.95 (95% CI 1.26, 3.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) in favor of ART. Safety endpoints showed no adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ART is a safe and effective non\u2010pharmacologic alternative for the treatment of nasal congestion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.23284","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:43:37Z","timestamp":1697060617000},"page":"919-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Acoustic resonance therapy is safe and effective for the treatment of nasal congestion in rhinitis: A randomized sham\u2010controlled trial"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-8010","authenticated-orcid":false,"given":"Amber U.","family":"Luong","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery McGovern Medical School of The University of Texas Health Science Center at Houston  Houston Texas USA"},{"name":"Center for Immunology and Autoimmune Diseases The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases McGovern Medical School of The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-5786","authenticated-orcid":false,"given":"Michael","family":"Yong","sequence":"additional","affiliation":[{"name":"Pacific Neuroscience Institute  Santa Monica California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-4675","authenticated-orcid":false,"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-0522","authenticated-orcid":false,"given":"Bryant Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramesh","family":"Gopi","sequence":"additional","affiliation":[{"name":"Sound Health Systems  Los Altos California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Mohan","sequence":"additional","affiliation":[{"name":"Sound Health Systems  Los Altos California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Johnson","sequence":"additional","affiliation":[{"name":"San Francisco Otolaryngology Medical Group  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"DeMera","sequence":"additional","affiliation":[{"name":"DeMera Allergy  Fresno California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-8861","authenticated-orcid":false,"given":"Benjamin S.","family":"Bleier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mass Eye and Ear Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.s8077"},{"key":"e_1_2_10_3_1","unstructured":"KaloramaInformation.Global Over\u2010The\u2010Counter (OTC) drug markets.2018.https:\/\/kaloramainformation.com\/product\/global\u2010over\u2010the\u2010counter\u2010otc\u2010drug\u2010markets\/"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053\u2010200422060\u201000002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.08.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.13.11"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202\u2010138BC"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.05.039"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22877"},{"key":"e_1_2_10_11_1","unstructured":"MeliadisC JohnsonJ ZhuW et\u00a0al.Estimating maxillary sinus dimesions using smartphone camera. In:The Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). IEEE;2023."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20132222.2009.03381.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20132288\u20103\u201321"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijoy.IJOY_32_18"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22988"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"211","article-title":"Current devices of respiratory physiotherapy","volume":"12","author":"Hristara\u2010Papadopoulou A","year":"2008","journal-title":"Hippokratia"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268622"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.019703"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00379063"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.6.8970383"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1976.113.1.92"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22537"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/MDER.S212207"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3603"},{"issue":"3","key":"e_1_2_10_27_1","first-page":"148","article-title":"Rhinitis medicamentosa","volume":"16","author":"Ramey JT","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1686"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/AAP.2008.29.3126"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112459"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000670\u20100"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819832277"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117002080"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T06:21:38Z","timestamp":1714026098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.23284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/alr.23284"],"URL":"https:\/\/doi.org\/10.1002\/alr.23284","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]},"assertion":[{"value":"2023-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}