{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:22:03Z","timestamp":1791645723001,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No studies have investigated the systemic and local sinonasal profile of obesity\u2010related chronic rhinosinusitis (CRS), despite its observed association in recent retrospective studies. The objectives of our study were to assess the impact of obesity on the clinical and cytokine profile of patients with CRS and evaluate treatment response with functional endoscopic sinus surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study at the Cleveland Clinic that included patients with CRS (<jats:italic>n<\/jats:italic>\u00a0=\u00a054) between December 2021 and September 2022. Data collection included demographics, body mass index (BMI), comorbidities, baseline sinonasal outcome test scores, baseline radiologic scores (Lund\u2013Mackay), postoperative sinonasal outcome test scores (at 3\u20134 months), and local and systemic alarmins\/T\u2010helper cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 54 CRS patients, there were 20 CRS patients without nasal polyps (37%) and 34 with nasal polyps (63%). Patients were categorized based on obesity (BMI \u2265 30\u00a0kg\/m<jats:sup>2<\/jats:sup>). Obese CRS patients had lower systemic alarmins (interleukin [IL]\u201033 and Thymic stromal lymphopoietin (TSLP)) compared to non\u2010obese CRS patients (IL\u201033: 744.2\u00a0\u00b1\u00a01164.6 pg\/mL vs. 137.5\u00a0\u00b1\u00a0320.0 pg\/mL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005; TSLP: 627.7\u00a0\u00b1\u00a01806.3 pg\/mL vs. 28.1\u00a0\u00b1\u00a085.4 pg\/mL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017). CRS patients with nasal polyps with BMI \u226530\u00a0kg\/m<jats:sup>2<\/jats:sup> had higher postoperative sinonasal outcome test scores and lower levels of nasal eotaxin\u20103 and IL\u201033 compared to BMI &lt;30\u00a0kg\/m<jats:sup>2<\/jats:sup> counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, patients with obese CRS and nasal polyps displayed diminished levels of intranasal alarmins and reduced intranasal eotaxin\u20103. These results potentially imply the presence of a unique, obese type 2\u2010low CRS phenotype that warrants further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23304","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T06:47:34Z","timestamp":1700808454000},"page":"1036-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessing the clinico\u2010immunological profile of patients with obesity and chronic rhinosinusitis"],"prefix":"10.1002","volume":"14","author":[{"given":"Mohamad R.","family":"Chaaban","sequence":"first","affiliation":[{"name":"Head and Neck Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewal","family":"Asosingh","sequence":"additional","affiliation":[{"name":"Lerner Research Institute Cleveland Clinic 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