{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:38:35Z","timestamp":1767839915794,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1I1A3A01061632"],"award-info":[{"award-number":["2019R1I1A3A01061632"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interleukin\u00a0(IL)\u201033, when cleaved into smaller fragments by proteases, becomes hyperactive, contributing to allergic inflammation. Povidone\u2010iodine (PVP\u2010I) is an iodine\u2010based compound that exhibits antimicrobial properties and inhibits proteases. This study aimed to investigate whether PVP\u2010I treatment inhibits IL\u201033 cleavage, improves allergic rhinitis (AR) symptoms, and suppresses allergic inflammation in a mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In vitro experiments using full\u2010length recombinant human IL\u201033 and allergens, including house dust mites or <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> 1, were conducted using western blotting. Fifty BALB\/c mice were divided into five groups: control (CON), AR with phosphate\u2010buffered saline treatment (AR), PVP\u2010I treatment (AR\u00a0+\u00a0PVP), <jats:italic>trans<\/jats:italic>\u2010epoxysuccinyl\u2010L\u2010leucylamido(4\u2010guanidino)butane (E64) treatment (AR\u00a0+\u00a0E64), and dexamethasone treatment (AR\u00a0+\u00a0Dexa). Nasal symptom scores, including rubbing and sneezing, were measured. The cytokine levels in the nasal lavage fluid (NLF) and the concentration of immunoglobulins in the blood serum were assessed. Nasal mucosa from each group was used for reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) and histological analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PVP\u2010I treatment reduced nasal symptoms, suppressed allergic inflammation, and decreased the levels of IL\u201033, IL\u20105, and IL\u201013 in the NLF and total immunoglobulin E (IgE) and specific IgE in the serum. Histopathological analysis revealed a reduction in the number of eosinophils and goblet cells in the nasal mucosa of the AR\u00a0+\u00a0PVP group when compared to the AR group. RT\u2010PCR and immunofluorescence staining confirmed the downregulation of genes and proteins associated with allergic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that nasal irrigation with PVP\u2010I may be a promising therapeutic option for managing AR by inhibiting IL\u201033 activation and suppressing allergic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23308","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T18:40:48Z","timestamp":1702320048000},"page":"1046-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nasal instillation of povidone\u2010iodine ameliorates ongoing mucosal inflammation in a pre\u2010sensitized murine model of Der p1\u2010induced allergic rhinitis"],"prefix":"10.1002","volume":"14","author":[{"given":"Jae\u2010Yoon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Research Institute for Medical Science Chungnam National University College of Medicine  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Ra","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Research Institute for Medical Science Chungnam National University College of Medicine  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Research Institute for Medical Science Chungnam National University College of Medicine  Daejeon South 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