{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:34Z","timestamp":1777581394748,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504100"],"award-info":[{"award-number":["2022YFC2504100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201254"],"award-info":[{"award-number":["82201254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271139"],"award-info":[{"award-number":["82271139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970850"],"award-info":[{"award-number":["81970850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970856"],"award-info":[{"award-number":["81970856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Itching is a troublesome symptom that disturbs patients with allergic rhinitis (AR). The molecular mechanisms underlying itching in AR need to be further illuminated. The aim of this study was to investigate the role of epithelial cell\u2010derived interleukin\u201031 (IL\u201031) in nasal itching in AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 33 patients and 20 healthy control subjects were enrolled in this prospective study. The disease severity of patients with AR was assessed by the total visual analog scale score. The levels of IL\u201031, cysteinyl leukotriene receptor 1 (CysLT1R), and CysLT2R in the nasal brush specimens from the enrolled subjects were measured by quantitative real\u2010time polymerase chain reaction (RT\u2013PCR) and immunohistochemical staining. The expression of CysLT2R in a human nasal epithelial cell line (HNEpC) was assessed by immunofluorescence staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control subjects, the protein and mRNA levels of IL\u201031 and CysLT2R were significantly increased in patients with AR. Higher levels of IL\u201031 and CysLT2R in nasal epithelial cells were associated with itching but not nasal congestion, rhinorrhea, or sneezing in AR. A significant relationship was found between IL\u201031 and CysLT2R in nasal epithelial cells, with a correlation coefficient of 0.93. Furthermore, RT\u2013PCR and immunofluorescence staining revealed that IL\u201031 directly induced CysLT2R expression in HNEpCs. Nasal steroid treatment inhibited IL\u201031 and CysLT2R expression in 13 patients with AR in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nasal epithelial cell\u2010derived IL\u201031 might be associated with itching symptoms via CysLT2R in AR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23311","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T11:55:01Z","timestamp":1702468501000},"page":"1070-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The IL\u201031\/CysLT2R axis is associated with itching in patients with allergic rhinitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-5721","authenticated-orcid":false,"given":"Kun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Eye &amp; ENT Hospital Fudan University  Shanghai P. R. China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor (2018RU003) Chinese Academy of Medical Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Clinical Allergy Center The First Affiliated Hospital Nanjing Medical University  Nanjing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Eye &amp; ENT Hospital Fudan University  Shanghai P. R. China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor (2018RU003) Chinese Academy of Medical Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Eye &amp; ENT Hospital Fudan University  Shanghai P. R. China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing P. R. China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Disease Chinese Academy of Medical Sciences  Beijing P. R. 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