{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:19Z","timestamp":1791301279870,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minimally invasive temperature\u2010controlled radiofrequency (TCRF) ablation of the posterior nasal nerve (PNN) demonstrated a significant larger treatment effect on the symptom burden of chronic rhinitis patients than a sham control (no energy delivery) at the 3\u2010month primary endpoint of this trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010year posttreatment outcomes for patients treated in a prospective, multicenter, patient\u2010blinded randomized controlled trial were determined by combining the index active treatment\u2010arm and index control\u2010arm crossover patients into a single group (after the primary endpoint) to evaluate the treatment effect durability and long\u2010term effects on concomitant chronic rhinitis medication usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean baseline reflective total nasal symptom score (rTNSS) was 8.2 (95% confidence interval [CI], 7.9\u20138.6; <jats:italic>N<\/jats:italic>\u00a0=\u00a0104). At 2 years (<jats:italic>N<\/jats:italic>\u00a0=\u00a079), the mean change in rTNSS was \u22125.3 (95% CI, \u22125.8 to \u22124.8; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; 64.6% improvement). The 2\u2010year responder rate (\u226530% improvement in rTNSS) was 87.3% (95% CI, 78.0\u201393.8). All four components of the rTNSS (rhinorrhea, congestion, sneezing, and nasal itching) showed significant improvement over baseline, with rhinorrhea and congestion showing the most improvement. Postnasal drip and cough symptoms were also significantly improved. At 2 years, 81.0% (95% CI, 70.6\u201389.0) reported a minimal clinically important difference of \u22650.4\u2010point improvement in the mini\u2010rhinoconjunctivitis quality of life questionnaire score. Of 56 patients using chronic rhinitis medications at baseline, 25 of 56 (44.6%) either stopped all medication use (7\/56 [12.5%]) or stopped\/decreased (18\/56 [32.1%]) use of \u22651 medication class at 2 years. No serious adverse events related to the device\/procedure were reported over 2 years.<\/jats:p><jats:p>To determine the potential effect of patients who left the trial over 2 years on the responder rate, the responder statuses of the 14 patients with follow\u2010up data who were lost to follow\u2010up\/withdrew\/died were imputed by the last observation carried forward and the responder statuses of all nine patients who had an additional nasal procedure were imputed to nonresponder, resulting in a 2\u2010year responder rate of 79.4% (95% CI, 70.3\u201386.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TCRF ablation of the PNN is safe and resulted in a significant and sustained reduction in chronic rhinitis symptom burden through 2 years and a substantial reduction in concomitant medication burden.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23315","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T23:24:10Z","timestamp":1706138650000},"page":"1182-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Temperature\u2010controlled radiofrequency ablation for the treatment of chronic rhinitis: Two\u2010year outcomes from a prospective multicenter trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Masayoshi","family":"Takashima","sequence":"first","affiliation":[{"name":"The Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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