{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:14:52Z","timestamp":1789578892784,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous response to medical\/surgical treatments based on endotypes. Data correlating biomarkers and severity of the disease are lacking. We aimed to determine if IL\u20105 and calprotectin may be useful in defining severity of disease and identifying uncontrolled patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a case\u2013control study including 81 patients with diffuse CRSwNP who underwent at least one previous surgery and treated with intranasal steroids. We enrolled 39 uncontrolled patients (SNOT\u201022\u00a0\u2265\u00a040 and two or more cycles of systemic corticosteroids in last year) (Group A) and 42 controlled one (SNOT\u201022\u00a0&lt;\u00a040 and less than two cycles of systemic corticosteroids in last year) (Group B). We analyzed IL\u20105 and calprotectin in both nasal secretions and nasal polyp tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Calprotectin and IL\u20105 were significantly higher in Group A in both secretions and tissue, and the higher the number of previous surgeries, the higher the levels detected in nasal secretions. At univariate analyses, smoking, asthma, non\u2010steroidal anti\u2010inflammatory drugs\u2010exacerbated respiratory disease (NSAID\u2010ERD), blood eosinophilia, neutrophils, and eosinophils at nasal cytology were significantly associated with uncontrolled disease. Multivariate analyses showed that asthma, NSAID\u2010ERD, and IL\u20105 in nasal secretion\/polyp tissue were significantly related to the risk of uncontrolled disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that asthma, NSAID\u2010ERD, and IL\u20105 in nasal secretions\/tissue may be helpful to identify more severe patients, as they are related to the risk of uncontrolled disease. Nonetheless, high levels of calprotectin and neutrophilia were also observed in uncontrolled patients, especially after multiple surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.23319","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T18:24:02Z","timestamp":1706120642000},"page":"1195-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Correlation between inflammatory biomarkers and disease control in chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De Corso","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology and Head\u2010Neck Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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Elisabetta","family":"Onori","sequence":"additional","affiliation":[{"name":"Molecular and Genomic Diagnostics Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"di Cesare","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Francesco","family":"Mastrapasqua","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sarlo","sequence":"additional","affiliation":[{"name":"Unit of Chemistry, Biochemistry and Molecular Biology Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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