{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:07Z","timestamp":1792270627275,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","award":["NCT03280550"],"award-info":[{"award-number":["NCT03280550"]}],"id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","award":["NCT03280537"],"award-info":[{"award-number":["NCT03280537"]}],"id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","award":["NCT03478930"],"award-info":[{"award-number":["NCT03478930"]}],"id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have high incidence of sleep impairment. We evaluated the impact of omalizumab treatment on sleep characteristics and associated health status in patients with CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prespecified exploratory analysis assessed outcomes from patients included in the POLYP 1 and POLYP 2 phase 3 clinical trials and the open\u2010label extension. Sleep was assessed by the sleep domain of the Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022; MCID\u00a0&gt;\u00a04 in patients with CRS) and the Medical Outcomes Study Sleep Scale (MOS\u2010Sleep). Health status was assessed by Healthy Days Core Module (HDCM) and sinonasal\u2010specific Patient Global Impression of Change (PGIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Omalizumab improved sleep as assessed by the SNOT\u201022 sleep domain. At week 24, adjusted mean (95%CI) SNOT\u201022 sleep scores had reduced from baseline by \u22128.5 (\u20139.9 to \u20137.1) with omalizumab versus \u20132.7 (\u20134.1 to \u20131.3) with placebo. At week 52 (all patents on OMA), adjusted mean (95%CI) SNOT\u201022 sleep scores had reduced from baseline by \u221210.1 (\u201311.4 to \u20138.7) with omalizumab. Improvements were observed in all eight items of the SNOT\u201022 sleep domain: difficulty falling asleep, fatigue, frustration\/restlessness\/irritability, lack good night's sleep, reduced concentration, reduced productivity, wake up tired, and wake up at night. In addition, omalizumab improved six of eight sleep outcomes on the MOS\u2010Sleep scale. There were concurrent improvements in HDCM and PGIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Omalizumab improved sleep and self\u2010reported health status in patients with CRSwNP. This contributes to evidence that omalizumab provides value for patients beyond the reduction of sinonasal symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23322","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T13:05:44Z","timestamp":1704891944000},"page":"1163-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Omalizumab improves sleep and health status for patients with chronic rhinosinusitis with nasal polyps: An analysis of randomized clinical trials"],"prefix":"10.1002","volume":"14","author":[{"given":"Eli O.","family":"Meltzer","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Rhinology Unit &amp; Smell Clinic ENT Department Hospital Clinic IDIBAPS Universitat de Barcelona CIBERES  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnie","family":"Ko","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Saenz","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Steinke","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Millette","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory Department of Otorhinolaryngology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-06953-3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2022.02.008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2022.02.011"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2022.02.009"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.03.006"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2022.02.012"},{"key":"e_1_2_13_8_1","first-page":"13","article-title":"Quality of life in patients suffering from insomnia","volume":"9","author":"Ishak WW","year":"2012","journal-title":"Innov Clin Neurosci"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228533"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24040"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1294063"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.03.002"},{"key":"e_1_2_13_13_1","first-page":"343","article-title":"The GALEN rhinosinusitis cohort: chronic rhinosinusitis with nasal polyps affects health\u2010related quality of life","volume":"57","author":"Khan A","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215054352108"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.06.006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817737977"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb00807.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22025"},{"key":"e_1_2_13_19_1","unstructured":"Genentech.XOLAIR\u00ae(omalizumab) US prescribing information. Accessed June 7 2022:https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/103976s5239lbl.pdf"},{"key":"e_1_2_13_20_1","unstructured":"Genentech.XOLAIR\u00ae(omalizumab) summary of product characteristics. Accessed June 7 2022:https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/xolair\u2010epar\u2010product\u2010information_en.pdf"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino15.072"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.032"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.07.045"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22963"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-016-0120-0"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22967"},{"key":"e_1_2_13_28_1","unstructured":"SpitzerKL HaysRD MOS Sleep Scale: a manual for use and scoring version 1.0. Accessed July 20 2023:https:\/\/labs.dgsom.ucla.edu\/hays\/files\/view\/docs\/surveys\/sleep\/sleepman\u2010112603.pdf"},{"key":"e_1_2_13_29_1","unstructured":"National Center for Chronic Disease Prevention and Health Promotion.CDC HRQOL\u201314 Healthy Days Measure. Accessed June 08 2023.https:\/\/www.cdc.gov\/hrqol\/hrqol14_measure.htm"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2003.11.003"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.05.013"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29766"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211061442"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T16:05:27Z","timestamp":1719936327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.23322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/alr.23322"],"URL":"https:\/\/doi.org\/10.1002\/alr.23322","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}