{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:36:17Z","timestamp":1775918177691,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R25DC020151"],"award-info":[{"award-number":["R25DC020151"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWIC20A0"],"award-info":[{"award-number":["BESWIC20A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWICK22Y5"],"award-info":[{"award-number":["BESWICK22Y5"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is common in people with cystic fibrosis (PwCF). Rhinologic symptom prioritization and areas that influence CRS treatment choices, including pursuing endoscopic sinus surgery (ESS), remain understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult PwCF\u00a0+\u00a0CRS were enrolled at eight centers into a prospective, observational study (2019\u20132023). Participants were administered the 22\u2010SinoNasal Outcome Test (SNOT\u201022) survey and a modified SNOT\u201022 instrument examining symptom importance. We determined importance rankings for individual symptoms and SNOT\u201022 symptom importance subdomains in two sets of subgroups\u2014those pursuing ESS versus continuing medical management (CMT), and those on elexacaftor\/tezacaftor\/ivacaftor (ETI) versus not on ETI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 69 participants, the highest priorities were nasal congestion (<jats:italic>n<\/jats:italic>\u00a0=\u00a048, 69.6% important), post\u2010nasal discharge (32, 46.4%), facial pain (29, 43.3%), waking up tired (27, 39.1%), and fatigue (26, 37.7%). Those electing surgery (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) prioritized sleep and psychological dysfunction symptoms compared to those pursuing CMT (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) (sleep median score\u00a0=\u00a019.0 [interquartile range: 12.0, 25.0] vs. 4.5 [0.0, 12.8]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; psychological\u00a0=\u00a017.0 [7.0, 26.0] vs. 7.0 [0.0, 15.8]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). ETI users had comparable SNOT\u201022 total symptom importance scores to non\u2010ETI users (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.14). Non\u2010ETI users (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) showed a trend toward prioritizing sleep symptoms compared to ETI users (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) (13.0 [2.8, 22.3] vs. 6.0 [2.0, 17.0]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nasal congestion and post\u2010nasal discharge were top priorities reported by PwCF\u00a0+\u00a0CRS. Those electing surgery prioritized sleep and psychological symptoms, highlighting their importance in pre\u2010operative discussions. Non\u2010ETI users\u2019 prioritization of sleep improvement may highlight their unique disease impact and therapeutic needs; however, additional investigation is required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23332","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:44:04Z","timestamp":1707720244000},"page":"1282-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient perspectives on chronic rhinosinusitis in cystic fibrosis: Symptom prioritization in the era of highly effective modulator therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-4775","authenticated-orcid":false,"given":"Christine M.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-4858","authenticated-orcid":false,"given":"Ethan J.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob L.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Oregon Health Sciences University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-1626","authenticated-orcid":false,"given":"Jose L.","family":"Mattos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Division of Rhinology and Sinus Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0076-3166","authenticated-orcid":false,"given":"Karolin","family":"Markarian","sequence":"additional","affiliation":[{"name":"CTSI, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd E.","family":"Bodner","sequence":"additional","affiliation":[{"name":"Department of Psychology Portland State University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naweed I.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Vanderbilt Health  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia H.","family":"Eshaghian","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Getz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Colorado  Aurora Colorado 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Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7083","authenticated-orcid":false,"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Oregon Health Sciences University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey 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