{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:57:44Z","timestamp":1774533464738,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22\u2010item Sinonasal Outcomes Test (SNOT\u201022) has been shown to improve with treatment. This study aims to characterize SNOT\u201022 subdomain outcomes in SNM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with SNM were prospectively enrolled in a multi\u2010center patient registry. SNOT\u201022 scores were collected\u00a0at the time of diagnosis and through the post\u2010treatment period for up to 5 years. Multivariable regression analysis was used to identify drivers of variation in SNOT\u201022 subdomains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Note that 234 patients were reviewed, with a mean follow\u2010up of 22 months (3 months\u201364 months). Rhinologic, psychological, and sleep subdomains significantly improved versus baseline (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Subanalysis of 40 patients with follow\u2010up at all timepoints showed statistically significant improvement in rhinologic, extra\u2010nasal, psychological, and sleep subdomains, with minimal clinically important difference met between 2 and 5 years in sleep and psychological subdomains. Adjuvant chemoradiation was associated with worse outcomes in rhinologic (adjusted odds ratio (5.22 [1.69\u20138.66])), extra\u2010nasal (2.21 [0.22\u20134.17]) and ear\/facial (5.53 [2.10\u20138.91]) subdomains. Pterygopalatine fossa involvement was associated with worse outcomes in rhinologic (3.22 [0.54\u20135.93]) and ear\/facial (2.97 [0.32\u20135.65]) subdomains. Positive margins (5.74 [2.17\u20139.29]) and surgical approach\u2014combined versus endoscopic (3.41 [0.78\u20136.05])\u2014were associated with worse psychological outcomes.\u00a0Adjuvant radiation (2.28 [0.18\u20134.40]) was associated with worse sleep outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra\u2010nasal, psychological, and sleep subdomains.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23338","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:04:57Z","timestamp":1708344297000},"page":"1314-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SNOT\u201022 subdomain outcomes following treatment for sinonasal malignancy: A prospective, multicenter study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-4280","authenticated-orcid":false,"given":"David R.","family":"Grimm","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-5442","authenticated-orcid":false,"given":"Daniel M.","family":"Beswick","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-4316","authenticated-orcid":false,"given":"Sabrina L.","family":"Maoz","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California Los Angeles Los Angeles California 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