{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:45:42Z","timestamp":1790621142535,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Surgical techniques for sellar reconstruction include no reconstruction, use of synthetic materials, autologous grafts, and\/or vascularized flaps. The aim of this study was to conduct a multi\u2010center study comparing the efficacy and postoperative morbidity associated with different sellar reconstruction techniques.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective chart review of patients who underwent endoscopic transsphenoidal surgery for pituitary tumors from five participating sites between January 2021 and March 2023 was performed. The variables included demographics, tumor characteristics, reconstruction technique, postoperative cerebrospinal fluid leak (CSF) leak, and 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) scores. Comparisons of postoperative complications, SNOT\u201022 scores, and duration of surgery by type of onlay reconstruction were evaluated using Fisher's exact test, analysis of variance, and Kruskal\u2012Wallis test.<\/jats:p><\/jats:sec>Results<\/jats:title>Five hundred and one patients were identified. The median tumor size was 2.1\u00a0cm, and 64% were non\u2010functioning. Intraoperative CSF leak was identified in 38% of patients. A total of 89% of patients underwent onlay reconstruction: 49% were reconstructed with mucosal grafts, 35% with nasoseptal flaps, and 5% with other onlay techniques. Nasoseptal flaps were utilized more frequently in the setting of giant pituitary adenomas (>3\u00a0cm), medial cavernous sinus wall resection, and high\u2010flow intraoperative CSF leaks. Cases who utilized mucosal grafts had an overall shorter operating time (median: 183 min vs. 240 min; p<\/jats:italic>\u00a0<\u00a00.001). Five postoperative CSF leaks were identified, and therefore, statistical analysis could not be performed for this complication.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The effectiveness and morbidity of different sellar reconstruction techniques are comparable. Vascularized flaps were utilized more frequently in the setting of larger tumors and high\u2010flow intraoperative CSF leaks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23382","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:15:02Z","timestamp":1718622902000},"page":"1558-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi\u2010center study on sellar reconstruction after endoscopic transsphenoidal pituitary surgery"],"prefix":"10.1002","volume":"14","author":[{"given":"Hawa M.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn M.","family":"Leland","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Mayo Clinic Rochester Minnesota 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