{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:37:10Z","timestamp":1783035430146,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Sinonasal malignancies (SNMs) adversely impact patients\u2019 quality of life (QOL) and are frequently identified at an advanced stage. Because these tumors are rare, there are few studies that examine the specific QOL areas that are impacted. This knowledge would help improve the care of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, multi\u2010institutional study, 273 patients with SNMs who underwent definitive treatment with curative intent were evaluated. We used the University of Washington Quality of Life (UWQOL) instrument over 5 years from diagnosis to identify demographic, treatment, and disease\u2010related factors that influence each of the 12 UWQOL subdomains from baseline to 5 \u2010years post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate models found endoscopic resection predicted improved pain (vs. nonsurgical treatment CI 2.4, 19.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and appearance versus open (CI 27.0, 35.0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) or combined (CI 10.4, 17.1, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Pterygopalatine fossa involvement predicted worse swallow (CI \u221210.8, \u22122.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and pain (CI \u221217.0, \u22124.0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Neck dissection predicted worse swallow (CI \u221214.8, \u22122.8, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), taste (CI \u221231.7, \u22121.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), and salivary symptoms (CI \u221228.4, \u22128.6, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Maxillary involvement predicted worse chewing (CI 9.8, 33.2; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and speech (CI \u221221.8, \u22125.4, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) relative to other sites. Advanced T stage predicted worse anxiety (CI \u221213.0, \u22122.0, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgical approach, management of cervical disease, tumor extent, and site of involvement impacted variable UWQOL symptom areas. Endoscopic resection predicted better pain, appearance, and chewing compared with open. These results may aid in counseling patients regarding potential QOL expectations in their SNM treatment and recovery course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23386","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:15:31Z","timestamp":1718622931000},"page":"1568-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-4316","authenticated-orcid":false,"given":"Sabrina L.","family":"Maoz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles  Los Angeles California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-5854","authenticated-orcid":false,"given":"Eric W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pennsylvania  Philadelphia Pennsylvania 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