{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:13:23Z","timestamp":1785194003246,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elexacaftor\/tezacaftor\/ivacaftor (ETI), a combination cystic fibrosis transmembrane receptor (CFTR) modulator, has demonstrated improved pulmonary outcomes in individuals with cystic fibrosis (CF). However, ETI's impact on functional endoscopic sinus surgery (FESS) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TriNetX Analytics Research Network, consisting of 120 million global de\u2010identified electronic medical records, was queried from 2012 to 2023 for subjects with CF who underwent sinus surgery.<jats:sup>1<\/jats:sup> Patients on ETI prior to FESS (<jats:italic>n<\/jats:italic>\u00a0=\u00a06,056) were propensity score matched to control individuals with CF not on CFTR modulators (<jats:italic>n<\/jats:italic>\u00a0=\u00a037,906) and those on other FDA\u2010approved CFTR modulators (tezacaftor\/ivacaftor, lumacaftor\/ivacaftor, and ivacaftor) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02437) based on relevant factors. The primary outcome was the absolute risk reduction (ARR) of undergoing FESS. Secondary outcomes included ARR of CF\u2010related pulmonary exacerbations and hospital admission from 0 to 6, 6 to 12, and 12 to 24 months following FESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ETI use demonstrated a significant ARR for FESS when compared to CF patients not on CFTR modulators (2.12%; 95% confidence interval [CI] 1.5\u20132.75; <jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a00.0001) and those on other CFTR modulators (4.7%; 95% CI 3.54\u20135.85; <jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a00.0001). No significant differences occurred in secondary outcomes between ETI and non\u2010CFTR modulator groups, except for reduced CF\u2010related pulmonary exacerbations from 0 to 6 months post\u2010FESS. Additionally, a significant reduction in pulmonary exacerbations was observed at all time points and hospital admissions within 6 months following FESS compared to those using other CFTR modulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large dataset, CF patients on ETI demonstrated significantly reduced risk of FESS, pulmonary exacerbations, and hospital admission compared to patients not on CFTR modulators or those on other CFTR modulators, suggesting improved sinonasal disease and overall health status in CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23400","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T14:04:37Z","timestamp":1720015477000},"page":"1692-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of elexacaftor\/tezacaftor\/ivacaftor CFTR modulator therapy on rates of endoscopic sinus surgery in cystic fibrosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-9613","authenticated-orcid":false,"given":"Graham","family":"Pingree","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Bentan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Virginia Commonwealth University Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Virginia Commonwealth University Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-5700","authenticated-orcid":false,"given":"Theodore","family":"Schuman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Virginia Commonwealth University Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14\u20131997"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116120"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"issue":"1589","key":"e_1_2_5_5_1","first-page":"5","article-title":"Elexacaftor\/tezacaftor\/ivacaftor (Trikafta) for cystic fibrosis","volume":"62","year":"2020","journal-title":"Med Lett Drugs 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