{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:41:22Z","timestamp":1790084482736,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWIC20A0"],"award-info":[{"award-number":["BESWIC20A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWIC22Y5"],"award-info":[{"award-number":["BESWIC22Y5"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Sociodemographic status (SDS) including race\/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a prospective, multi\u2010institutional study, adult PwCF completed the 22\u2010Question SinoNasal Outcome Test (SNOT\u201022), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD\u2010NS), and Cystic Fibrosis Questionnaire\u2010Revised (CFQ\u2010R). Lund\u2013Kennedy scores, sinus computed tomography, and clinical data were collected. Data were analyzed across race\/ethnicity, sex, and socioeconomic factors using multivariate regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010three PwCF participated with a mean age of 34.7\u00a0\u00b1\u00a010.9 years and 49 (67.1%) were female. Linear regression identified that elexacaftor\/tezacaftor\/ivacaftor (ETI) use (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u20124.09, 95% confidence interval [CI] [\u20126.08, \u20122.11],\n p<\/jats:italic>\n \u00a0<\u00a00.001), female sex (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u20122.14, 95% CI [\u20124.11, \u20120.17],\n p<\/jats:italic>\n \u00a0=\u00a00.034), and increasing age (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u20120.14, 95% CI [\u20120.22, \u20120.05],\n p<\/jats:italic>\n \u00a0=\u00a00.003) were associated with lower\/better endoscopy scores. Private health insurance (\n \u03b2<\/jats:italic>\n \u00a0=\u00a017.76, 95% CI [5.20, 30.32],\u00a0\n p<\/jats:italic>\n \u00a0=\u00a00.006) and >16 educational years (\n \u03b2<\/jats:italic>\n \u00a0=\u00a013.50, 95% CI [2.21, 24.80],\n p<\/jats:italic>\n \u00a0=\u00a00.020) were associated with higher baseline percent predicted forced expiratory volume in one second (ppFEV\n 1<\/jats:sub>\n ). Medicaid\/Medicare insurance was associated with worse endoscopy scores, CFQ\u2010R respiratory scores, and ppFEV\n 1<\/jats:sub>\n (all\n p<\/jats:italic>\n \u00a0<\u00a00.017), and Hispanic\/Latino ethnicity was associated with worse SNOT\u201022 scores (\n p<\/jats:italic>\n \u00a0=\u00a00.047), prior to adjustment for other cofactors. No other SDS factors were associated with SNOT\u201022, QOD\u2010NS, or SIT scores.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Differences in objective measures of CRS severity exist among PwCF related to sex, age, and ETI use. Variant status and race did not influence patient\u2010reported CRS severity measures or olfaction in this study. Understanding how these factors impact response to treatment may improve care disparities among PwCF.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trials<\/jats:title>\n NCT04469439<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.23402","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:38:21Z","timestamp":1720179501000},"page":"1700-1713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-4858","authenticated-orcid":false,"given":"Ethan J.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery University of California Los Angeles California 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