{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:46:01Z","timestamp":1784691961898,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1F1A1076298"],"award-info":[{"award-number":["NRF\u20102022R1F1A1076298"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the treatment outcomes in patients with advanced\u2010stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The clinical data of 38 patients with advanced\u2010stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.1. Patients with complete remission or partial remission were defined as responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen (44.7%) patients responded to IC. The response rate was higher in patients with high Hyams grade tumor (III\/IV) compared to those with low\u2010grade tumors (I\/II) (60% vs. 22.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038). Overall, the 5\u2010year cancer\u2010specific survival (CSS) rate was 76.0%. Among nonresponders to IC, a significant difference in 5\u2010year CSS rates was observed between surgery with adjuvant radiotherapy (RT) (100%) versus definitive RT or chemoradiotherapy (CRT) (68.6%) (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). However, for responders, there was no significant difference in 5\u2010year CSS rates between surgery with adjuvant therapy (75%) and definitive RT or CRT (51.1%) (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.536). When only high\u2010grade tumors were considered among responders, the 5\u2010year CSS rate was significantly higher in patients who received RT or CRT (51.4%) compared to those who underwent surgery with adjuvant therapy (0%) (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In advanced\u2010stage ONB, RT or CRT may be preferable for high\u2010grade tumor responding to IC. Higher response rate and a potential role for induction IC in determining the optimal definitive treatment modality suggest a positive role for advanced\u2010stage high\u2010grade ONB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23428","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:53:52Z","timestamp":1724147632000},"page":"1882-1891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of induction chemotherapy in advanced\u2010stage olfactory neuroblastoma"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-4471","authenticated-orcid":false,"given":"Sung\u2010Woo","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Seongnam South 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