{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:17:13Z","timestamp":1792034233058,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve pulmonary outcomes in cystic fibrosis (CF) by stabilizing the CFTR protein on respiratory epithelial surfaces. To determine the efficacy of CFTR modulators on sinonasal outcomes in patients with CF, we performed a meta\u2010analysis of clinical trials to date that include functional and radiographic evidence of sinus disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>English full\u2010text articles were searched in PubMed, Embase, and Scopus databases. Two reviewers screened articles and a third reviewer resolved disagreements. Articles were included if they reported functional or radiological sinonasal outcomes in patients with CF before and after CFTR modulator therapies. Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines were followed, and the risk of bias in non\u2010randomized studies of interventions tool was used for quality assessment. The generic inverse variance method with random effects model was used for meta\u2010analysis. Standardized mean difference (SMD) and mean difference (MD) were used as effect measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven prospective and two retrospective studies representing 248 patients were included in this analysis. There was a significant improvement in sinonasal outcome test\u201022 scores on elexacaftor\u2012tezacaftor\u2012ivacaftor (MD\u00a0=\u00a012.80, [95% confidence interval, CI: 10.46\u201215.13], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>n<\/jats:italic>\u00a0=\u00a0222), with no heterogeneity detected (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.820). There was also a significant improvement in Lund\u2012Mackay scores (SMD\u00a0=\u00a01.25, [95% CI: 0.58\u20121.91], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>n<\/jats:italic>\u00a0=\u00a088), with heterogeneity detected (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a067%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CFTR modulators improve functional and radiologic sinonasal outcomes. Given the utility of CFTR modulators, the treatment paradigm for CF\u2010related chronic rhinosinusitis promises to evolve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23439","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:10:17Z","timestamp":1725009017000},"page":"1607-1617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional and radiological sinonasal outcomes of CFTR modulators for sinus disease in cystic fibrosis: A meta\u2010analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Tristan","family":"Tham","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felisha A.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob R.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew I.","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"},{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-6012","authenticated-orcid":false,"given":"Michael T.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Chaskes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-5134","authenticated-orcid":false,"given":"Charles C. 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