{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:39:47Z","timestamp":1786372787722,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031028","name":"Rajavithi Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tissue eosinophil count (TEC) is recommended for defining Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). TEC is usually assessed by a one\u2010time polyp biopsy. Because TEC may change over time, its reliability for diagnosing type 2 CRSwNP has not been previously assessed. This study aims to explore whether TEC fluctuates across different time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with CRSwNP were prospectively recruited at Rajavithi Hospital, Thailand. Participants who had used any form of steroids within 4 weeks were excluded. Polyps were taken for TEC evaluation upon recruitment and repeated at 3 and 6 months. Participants were assessed using the 22\u2010items Sinonasal Outcome Test (SNOT\u201022), Lund\u2013Kennedy endoscopic score (LKES), blood eosinophil count, and its percentage at each time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven participants were enrolled. The medians (Quartiles 1\u20133) of TEC were 17 (4\u201353.5), 19 (5\u201347.5), and 21 (4.5\u201351) cells\/high\u2010powered field at 0, 3, and 6 months, respectively. Friedman's two\u2010way analysis of variance showed no statistical differences across the three time points for TEC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.53), blood eosinophil counts (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.61), blood eosinophil percentages (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.23), SNOT\u201022 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.21), or LKES (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.23). TEC significantly correlated with blood eosinophil counts at 0 and 3 months and with blood eosinophil percentages at 0, 3, and 6 months (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed that TEC did not significantly fluctuate over time, aligning with blood eosinophil levels, SNOT\u201022, and LKES. This stability within the 6\u2010month period supports the reliability of TEC from a single biopsy for clinical use in managing CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23494","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:08:54Z","timestamp":1734354534000},"page":"395-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fluctuation of tissue eosinophils in chronic rhinosinusitis with nasal polyp"],"prefix":"10.1002","volume":"15","author":[{"given":"Kunjira","family":"Sombutpiboonphon","sequence":"first","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornkiat","family":"Snidvongs","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranath","family":"Lawpoolsri","sequence":"additional","affiliation":[{"name":"Department of Tropical Hygiene Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutpacha","family":"Chotikawichean","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Rajavithi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patlada","family":"Kowatanamongkon","sequence":"additional","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittichai","family":"Mongkolkul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-6767","authenticated-orcid":false,"given":"Wirach","family":"Chitsuthipakorn","sequence":"additional","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0800-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.06.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000602"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892419896239"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"MC08","article-title":"Significance of blood eosinophil count in patients with chronic rhinosinusitis with nasal polyposis","volume":"11","author":"Sreeparvathi A","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147917.43615.c0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-017-0102-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22517"},{"issue":"29","key":"e_1_2_11_14_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12901-017-0047-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.9.1102"},{"key":"e_1_2_11_18_1","first-page":"177","article-title":"Biostatistics\u2014A foundations for analysis in the health sciences","author":"Daniel WW","year":"1995","journal-title":"John Wiley & Son, Inc."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin13.217"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00133603"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22194"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22214"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23721"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13536"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07746-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin24.090"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3477"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23282"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4231"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25147"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21221"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.079"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin18.068"}],"container-title":["International Forum of Allergy &amp; 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