{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:07:10Z","timestamp":1784524030019,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study explores the effect of sociodemographics and comorbidities on the calculated minimal clinically important difference (MCID) for 22\u2010item Sinonasal Outcome Test (SNOT\u201022) scores in patients with medically treated chronic rhinosinusitis (CRS). The importance of delineating a threshold to indicate clinically meaningful changes perceived by a patient is well acknowledged, yet the influence of patient\u2010specific factors on MCID has not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRS (<jats:italic>n<\/jats:italic> = 221) presenting to a tertiary care practice reported their change in disease burden with anchor questions following CRS\u2010directed medical treatment. Baseline sociodemographics, pertinent history, and comorbid conditions, as well as pre\u2010 and post\u2010treatment SNOT\u201022 scores were also collected. Adjusted logistic regression was utilized to determine the factors influencing MCID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 221 patients, 43.9% (<jats:italic>n<\/jats:italic> = 97) reported improvement following medical treatment. Gender, education level, depression, and migraine were identified as significant factors influencing perceived improvement. Our predictive model, incorporating these variables, achieved an area under the receiver operating characteristic curve of 0.818 (95% confidence interval [CI] = 0.762, 0.875), with a sensitivity of 74.4% and specificity of 77.9%. Changes in SNOT\u201022 scores were not strongly associated with perceived improvement in patients with depression (odds ratio [OR] = 1.06; 95% CI = 0.98, 1.14; <jats:italic>p<\/jats:italic> = 0.140). Conversely, patients with migraines perceived more pronounced improvements or deteriorations at the extremes of SNOT\u201022 score changes (OR = 0.84; 95% CI = 0.76, 0.93; <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings underscore the substantial impact of patient\u2010specific sociodemographics and comorbidities on the calculation of MCID values for the SNOT\u201022. This study advances our understanding of variability in MCID and demonstrates the complex milieu of factors affecting patients\u2019 perceived clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23510","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T19:35:27Z","timestamp":1736192127000},"page":"483-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patient Factors Influence Minimal Clinically Important Difference for the SNOT\u201022 in Medically Treated Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-5009","authenticated-orcid":false,"given":"Mohamed A.","family":"Aboueisha","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Washington  Seattle Washington USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-8141","authenticated-orcid":false,"given":"Felix E.","family":"Fern\u00e1ndez\u2010Penny","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Washington  Seattle Washington USA"},{"name":"Pritzker School of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector A.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Washington  Seattle Washington 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