{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T08:14:37Z","timestamp":1785572077570,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031028","name":"Rajavithi Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tissue eosinophil counts (TEC) might serve as a biomarker linking chronic rhinosinusitis (CRS) and the presence of adult\u2010onset asthma. This study aimed to determine if TEC in sinus mucosa\/polyps in CRS patients is an independent indicator of asthma and to identify its optimal cut\u2010off point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on primary CRS patients scheduled for surgery. All patients were assessed by a pulmonologist for asthma diagnosis. Tissues were collected during surgery and evaluated for TEC. Logistic regression and receiver operating characteristic analysis were used to determine significant factors and the optimal cut\u2010off points of TEC associated with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 103 CRS patients were included. Ten patients (9.7%) had underlying asthma, while 13 (12.6%) were first diagnosed by the pulmonologist. TEC \u226540 cells per high\u2010powered field (HPF) exhibited a significant correlation with asthma (area under the curve\u00a0=\u00a00.71, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The sensitivity of this cut\u2010off point was 0.70 (95% confidence interval [CI]\u00a0=\u00a00.47\u20130.87), and specificity was 0.66 (95% CI\u00a0=\u00a00.55\u20130.76). Positive predictive value and negative predictive value were 0.37 and 0.88, respectively. The cut\u2010off point significantly associated with the presence of asthma, with an adjusted odds ratio of 3.13 (95% CI\u00a0=\u00a01.05\u20139.35, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04), controlling for polyps, allergic rhinitis, and computerized tomography (CT) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TEC in CRS patients can help determine the presence of adult\u2010onset asthma, with an optimal threshold of \u226540 cells\/HPF. This threshold is significantly associated with asthma independent of polyps, allergy, and CT score.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23527","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:38:53Z","timestamp":1736343533000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tissue Eosinophils Threshold and its Association With Adult\u2010Onset Asthma in Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-9165","authenticated-orcid":false,"given":"Patlada","family":"Kowatanamongkon","sequence":"first","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-4718","authenticated-orcid":false,"given":"Kornkiat","family":"Snidvongs","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3958-1289","authenticated-orcid":false,"given":"Potjanee","family":"Korrungruang","sequence":"additional","affiliation":[{"name":"Department of Medicine Rajavithi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3961-2680","authenticated-orcid":false,"given":"Nutpacha","family":"Chotikawichean","sequence":"additional","affiliation":[{"name":"Department of Pathology Rajavithi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2681-2958","authenticated-orcid":false,"given":"Dichapong","family":"Kanjanawasee","sequence":"additional","affiliation":[{"name":"Center of Research Excellence in Allergy and Immunology Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Biodesign Innovation Center Department of Parasitology Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-7364","authenticated-orcid":false,"given":"Kittichai","family":"Mongkolkul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-6767","authenticated-orcid":false,"given":"Wirach","family":"Chitsuthipakorn","sequence":"additional","affiliation":[{"name":"Center of Excellence in Otolaryngology\u2014Head &amp; Neck Surgery Rajavithi Hospital  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1192284"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"565","article-title":"Chronic Rhinosinusitis With Nasal Polyps","volume":"4","author":"Stevens W. 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