{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:15Z","timestamp":1786976835973,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies have extensively explored new non\u2010invasive and side\u2010effect\u2010free therapeutic strategies for the treatment of allergic rhinitis (AR). Photobiomodulation therapy (PBMT) utilizes photons from the red to infrared spectrum to modulate biological processes, exhibiting anti\u2010inflammatory and regenerative properties. The objective of our study was to evaluate the efficacy of PBMT in patients with AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a randomized, placebo\u2010controlled, double\u2010blind clinical trial involving 62 patients with AR. Participants underwent PBMT twice weekly, totaling eight sessions over the course of 1 month. The control group consisted of 29 patients who received treatment with a non\u2010light\u2010emitting device, while 33 patients in the laser therapy group received a protocol of 6 J of red and infrared light administered intranasally, along with 1 J of infrared light applied externally to the nose. Objective, psychophysical, and subjective assessments of nasal obstruction and olfactory function were conducted both before and after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PBMT contributed to significant improvements in various nasal and respiratory parameters. The peak nasal inspiratory flow demonstrated significant improvement (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and the Nasal Obstruction Symptom Evaluation scale indicated notable enhancement in nasal obstruction (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.048). Additionally, the Rhinitis Control Assessment Test reflected significant symptom improvement over the past week (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035). However, the University of Pennsylvania Smell Identification Test showed no significant change in olfactory function (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.251).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that PBMT may serve as a promising therapeutic option for individuals with AR, providing an alternative for those who are unable to tolerate conventional medications. Furthermore, it demonstrates efficacy and safety as a viable treatment alternative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.23532","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T23:24:11Z","timestamp":1737329051000},"page":"594-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of Using Photobiomodulation Therapy in Allergic Rhinitis: A Placebo\u2010Controlled Randomized Clinical Trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Patr\u00edcia Costa","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Estadual de Londrina  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Oliveira","family":"Correia","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Medeiros Dias","family":"Lopes","sequence":"additional","affiliation":[{"name":"GEM  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Molossi","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-2337","authenticated-orcid":false,"given":"Marco Aur\u00e9lio","family":"Fornazieri","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina  Londrina Brazil"},{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"},{"name":"GEM  Londrina Brazil"},{"name":"Smell and Taste Center Department of Otorhinolaryngology: Head and Neck Surgery Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23090"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04017.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21385"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011085"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16607-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0280-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013783"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0331-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0279-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/2317-6431-2017-1967"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013772"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204328"},{"key":"e_1_2_6_16_1","first-page":"1691","volume-title":"Efficacy and Safety of Twice\u2010Daily Olopatadine\u2013Mometasone Combination Nasal Spray (GSP301) in the Treatment of Allergic Rhinitis: A Systematic Review and Meta\u2010Analysis","author":"Chen R.","year":"2022"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf4964"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0454-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2688-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12148"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bju068"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-80342010000400023"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942011000400011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1808-86942012000300011"},{"issue":"5","key":"e_1_2_6_25_1","first-page":"389","article-title":"Objective and Subjective Assessments of Nasal Obstruction in Children and Adolescents With Allergic Rhinitis","volume":"88","author":"Mendes A. 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