{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:52:45Z","timestamp":1774320765971,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Paediatric sinonasal disease is prevalent worldwide, giving rise to substantial healthcare costs and morbidity. However, there is a lack of sinus\u2010specific patient\u2010reported outcome measures (PROMs) tailored for children. This study aimed to evaluate existing PROMs against established validation criteria to determine whether a paediatric\u2010specific, validated instrument for assessing sinonasal disease currently exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline (Ovid), Embase (Ovid), Emcare (Ovid), and the Cochrane Library were searched from inception to January 2024. Eligibility was restricted to PROM development or content validity studies conducted in all children with sinonasal disease. Content validity was assessed using the COnsensus\u2010based Standards for the selection of health Measurement INstruments (COSMIN) methodology, with evidence graded using a modified GRADE approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five PROMs were identified: two for acute sinus disease (Sinus\u20105 [S5] and Paediatric Rhinosinusitis Symptom Scale [PRSS]), two for general rhinosinusitis (Sinonasal\u20105 [SN\u20105] and Modified Sinonasal Outcome Test\u201020 Young Persons Questionnaire [MSYPQ]) and one specific to primary ciliary dyskinesia (PCD; PCD quality of life [PCD\u2010QoL]). No content validity studies were included in the final analysis. The development of the S5, PRSS, SN\u20105 and MSYPQ was found to be inadequate, supported by low\u2010quality evidence, whereas the PCD\u2010QoL stood out as a well\u2010developed tool created using established evidence\u2010based guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among the assessed tools, only the PCD\u2010QoL met standards for use in clinical trials, highlighting the need for a dedicated instrument to track disease status and QoL in otherwise healthy children with sinonasal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23539","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:44:22Z","timestamp":1739958262000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Content Validity of Patient\u2010Reported Outcome Measures Developed for Assessing Disease\u2010Specific Quality of Life in Children With Sinonasal Disease: A Systematic Review"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-1634","authenticated-orcid":false,"given":"Isabelle","family":"Williams","sequence":"first","affiliation":[{"name":"Core Surgical Trainee, Guy's and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-1993","authenticated-orcid":false,"given":"Oloruntobi","family":"Rotimi","sequence":"additional","affiliation":[{"name":"University College Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Burrows","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospitals NHS Trust Truro UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annakan V.","family":"Navaratnam","sequence":"additional","affiliation":[{"name":"University College Hospitals NHS Foundation Trust London 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