{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:27:16Z","timestamp":1792124836567,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts patients\u2019 quality of life (QoL). Standard treatments include nasal irrigations, nasal steroids, systemic corticosteroids, and functional endoscopic sinus surgery (FESS). Uncontrolled severe CRSwNP treated with monoclonal antibodies (biologic drugs) gain better disease control, although some residual symptoms may persist. Combining biologic therapy with FESS could potentially reduce residual symptoms faster and for a longer period. Therefore, we aim to compare the effectiveness of combined FESS and biologic therapy against biologics alone in patients with severe CRSwNP.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n This randomised controlled trial (RCT) enrolled 58 patients with CRSwNP and type 2 inflammation who were randomly assigned to FESS or non\u2010FESS groups. All patients were treated with 100\u00a0mg of s.c. mepolizumab every 4 weeks for 6 months. Those in the FESS group underwent surgery 2 weeks after the first injection. Patients were assessed at baseline and after 6 months using the sino\u2010nasal outcome test\u201022 (SNOT\u201022), visual analog scale (VAS), nasal congestion score (NCS), and the smell identification test (16 sticks). Clinical evaluations were performed using rhinoscopy to identify nasal polyp scores (NPS).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both treatment groups significantly improved in terms of their SNOT\u201022 scores after 6 months of treatment (\n p<\/jats:italic>\n \u00a0<\u00a00.001). There were not significant differences between the two groups (\n p<\/jats:italic>\n = 0.055). Patients with large NPS (6\u20138) improved significantly in terms of their SNOT\u201022 scores when they underwent combined treatment (FESS and mepolizumab) compared with s.c. mepolizumab alone (\n p<\/jats:italic>\n \u00a0<\u00a00.05). They also exhibited improvements in \u0394NPS (\n p<\/jats:italic>\n \u00a0<\u00a00.001), VAS CRS (\n p<\/jats:italic>\n = 0.074), and NCS reduction (\n p<\/jats:italic>\n \u00a0<\u00a00.001) after undergoing combined treatment compared with those who had mepolizumab alone.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Patients with large polyp scores experienced significant improvements in their QoL (SNOT\u201022) and reduced NPS, NCS, and VAS CRS more when polyp burden was reduced with FESS in association with mepolizumab treatment compared to those treated with mepolizumab alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.23562","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:50:19Z","timestamp":1741693819000},"page":"724-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6\u2010Month Trial"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9716-6501","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Hom\u00f8e","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Aan\u00e6s","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Even","family":"Tidemandsen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haase Christiane","family":"Holbaek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubek","family":"Niclas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuelsen Grethe","family":"Badsberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology North Zealand Hospital Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larsen Bent Ivan","family":"Holmegaard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Backer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Centre for Physical Activity Research Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"7","article-title":"International Rhinology Journal European Position Paper on Rhinosinusitis and Nasal Polyps","volume":"1","author":"Fokkens W. J.","year":"2020","journal-title":"Epos 2020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.032"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/rhin19.184"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.489"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010023\u201001118\u20106"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"C.Bachert J. K.Han M.Wagenmann et\u00a0al. \u201cEUFOREA Expert Board Meeting on Uncontrolled Severe Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) and Biologics: Definitions and Management \u201dThe Journal of Allergy and Clinical Immunology147 no. 1 (2021): 29\u201236 https:\/\/doi.org\/10.1016\/j.jaci.2020.11.013.","DOI":"10.1016\/j.jaci.2020.11.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31881\u20101"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(21)00097\u20107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519228"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","unstructured":"L.Calus N.Van Bruaene C.Bosteels et\u00a0al. Twelve\u2010Year Follow\u2010Up Study After Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis With Nasal Polyposis Clinical and Translational Allergy9 (2019): 30 https:\/\/doi.org\/10.1186\/s13601\u2010019\u20100269\u20104.","DOI":"10.1186\/s13601-019-0269-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23219"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533\u2010023\u201000330\u20101"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41030\u2010019\u20100093\u2010y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000425"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23059"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818773065"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2019.12.1230"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin21.401"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15650"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.627"}],"container-title":["International Forum of Allergy & Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:15:32Z","timestamp":1751627732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.23562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/alr.23562"],"URL":"https:\/\/doi.org\/10.1002\/alr.23562","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2024-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}