{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:20Z","timestamp":1791301280139,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temperature\u2010controlled radiofrequency (TCRF) ablation of the posterior nasal nerve has been shown to improve chronic rhinitis (CR) symptoms and quality of life (QoL). This study assesses the durability of TCRF's effectiveness and safety 3\u00a0years post\u2010procedure in patients with perennial allergic CR and nonallergic CR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This prospective, multicenter, single\u2010blinded, randomized controlled trial included a sham control arm and long\u2010term follow\u2010up. Analysis combined patients from the active treatment and control crossover arms. Outcomes include reflective total nasal symptom score (rTNSS), postnasal drip (PND), and cough scores, as well as QoL measured by the Mini Rhinoconjunctivitis Quality\u2010of\u2010Life Questionnaire (MiniRQLQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 104 patients who underwent TCRF, 59 participated in the 3\u2010year follow\u2010up. The baseline mean rTNSS was 8.2 (95% confidence interval [95% CI, 7.9\u20138.6]), reduced to 3.5 (95% CI, 2.9\u20134.1) at 3\u00a0years, a 57.3% reduction and mean change of \u22124.7 (95% CI, \u22125.3 to \u22124.1; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Most patients (79.7%) were responders. Cough scores decreased from a mean baseline of 1.5 (95% CI, 1.3\u20131.7) to 0.7 (95% CI, 0.5\u20130.9; mean change, \u22120.8; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). PND symptoms were also reduced from 2.5 (95% CI, 2.4 \u2013 2.7) to 1.4 (95% CI, 1.2\u20131.7; mean change, \u22121.1; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). No severe adverse events were reported throughout the study, and no adverse events were reported between 24\u00a0months and 36\u00a0months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TCRF ablation of the posterior nasal nerve provided sustained safety and improvement in CR symptoms, cough, postnasal drip, and patient\u2010reported QoL at 3\u00a0years, supporting its long\u2010term safety and efficacy in CR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23577","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T12:38:34Z","timestamp":1743856714000},"page":"915-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["3\u2010Year Outcomes of Temperature\u2010Controlled Radiofrequency Ablation of the Posterior Nasal Nerve in Patients With Chronic Rhinitis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-3553","authenticated-orcid":false,"given":"J. Pablo","family":"Stolovitzky","sequence":"first","affiliation":[{"name":"The Department of Otolaryngology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[{"name":"Sacramento Ear Nose and Throat Medical and Surgical Group  Roseville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Silvers","sequence":"additional","affiliation":[{"name":"Madison ENT &amp; Facial Plastic Surgery  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"McDuffie","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Associates of Texas  McKinney Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dean","sequence":"additional","affiliation":[{"name":"Ear &amp; Sinus Institute  Fort Worth Texas USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Texas Tech Health Science Center  Lubbock Texas USA"},{"name":"Otorhinologic Research Institute  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Takashima","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology\u2014Head &amp; Neck Surgery Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Anatomy, Autonomic Nervous System","author":"Waxenbaum J. A.","year":"2025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764\u20101489.268"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31120"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211033400"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/21526575221096045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221109987"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23315"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2003.00420.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2009.03381.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23238"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2152656720946996"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23199"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39973"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30911"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci59320"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329\u20106895.1000168"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23259"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4141"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.23577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T15:00:46Z","timestamp":1756738846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.23577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/alr.23577"],"URL":"https:\/\/doi.org\/10.1002\/alr.23577","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"2024-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}