{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:50:05Z","timestamp":1783403405454,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Research is needed on treatments that prevent progression to long COVID\u201019 olfactory and gustatory dysfunction, which millions continue to suffer from. We sought to explore the utility of Paxlovid in decreasing rates of long COVID\u201019 smell and taste loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This case\u2013control study at a single tertiary medical center examined patients who were acutely infected with COVID\u201019 and received Paxlovid from December 2021 to September 2023 and age\u2010matched infected patients who did not receive Paxlovid. Occurrence of nasal congestion, rhinorrhea, facial pain\/pressure and smell\/taste loss were recorded both in the acute (&lt;30 days for nasal congestion, rhinorrhea, facial pain\/pressure; &lt;90 days for smell\/taste loss) and the long\u2010term settings for both groups. Chi\u2010square and <jats:italic>t<\/jats:italic>\u2010tests were used to compare the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 846 individuals had complete data (Paxlovid: 423, non\u2010Paxlovid: 423). Significantly more individuals in the Paxlovid group experienced nasal congestion (<jats:italic>p<\/jats:italic> &lt; 0.001) and rhinorrhea (<jats:italic>p<\/jats:italic> = 0.006) in the acute setting. However, resolution of these symptoms after 30 days did not differ between the Paxlovid and non\u2010Paxlovid groups (<jats:italic>p<\/jats:italic> = 0.375 and <jats:italic>p<\/jats:italic> = 0.316, respectively). Facial pressure did not differ between the two groups in either the acute or long\u2010term setting (<jats:italic>p<\/jats:italic> = 0.077 and <jats:italic>p<\/jats:italic> = 0.315).<\/jats:p><jats:p>In the acute setting, there was no significant difference between groups in the number of patients experiencing olfactory\/gustatory changes (<jats:italic>p<\/jats:italic> = 0.487). After taking Paxlovid however, individuals were less likely to experience long\u2010term olfactory\/gustatory changes (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early intervention with Paxlovid may decrease the risk of long COVID\u201019 smell\/taste changes. Further study with a randomized controlled trial would help providers know more definitively if they should consider this utility in preventing long\u2010term smell and taste loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.23612","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:13:59Z","timestamp":1748582039000},"page":"1094-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Paxlovid Is Associated With Lower Rates of Long COVID\u201019 Smell and Taste Disorders"],"prefix":"10.1002","volume":"15","author":[{"given":"Esther","family":"Wang","sequence":"first","affiliation":[{"name":"Caruso Department of Otolaryngology\u2010Head and Neck Surgery Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-982X","authenticated-orcid":false,"given":"Zara M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018963\u2010y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102639"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjaa081"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30802"},{"key":"e_1_2_7_6_1","article-title":"Prognosis and Persistence of Smell and Taste Dysfunction in Patients With Covid\u201019: Meta\u2010Analysis With Parametric Cure Modelling of Recovery Curves","volume":"378","author":"Tan B. 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