{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:16:37Z","timestamp":1790709397134,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa remain poorly understood. Cadherin\u201026 (CDH26), an epithelial adhesion molecule that binds to integrins \u03b14 (ITGA4) and \u03b1E, has been implicated in eosinophilic inflammation and may play a critical role in eosinophil recruitment and tissue infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the role and underlying mechanism of CDH26 in facilitating eosinophil transepithelial migration in patients with eCRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010cell ribonucleic acid (RNA) sequencing and immunohistochemistry (IHC) were performed on nasal tissues from patients with eCRSwNP, non\u2010eCRSwNP, chronic rhinosinusitis without nasal polyps (CRSsNP), and healthy controls to evaluate CDH26 expression. Human primary nasal epithelial cells (hPNECs) were stimulated in vitro with interleukin\u20104 (IL\u20104) or IL\u201013, and CDH26 expression was assessed via reverse transcription polymerase chain reaction (RT\u2010PCR), western blotting, and IHC. The effect of IL\u20104 receptor blockade using Dupilumab was evaluated in monolayer cultures. ITGA4 expression in EoL\u20101 eosinophil\u2010like cells was measured by flow cytometry, and their interaction with recombinant CDH26 was evaluated using cell adhesion and Transwell migration assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CDH26 expression was significantly upregulated in eCRSwNP tissues compared to that in other groups. IL\u20104 and IL\u201013 stimulation induced CDH26 expression in hPNECs, which was dose\u2010dependently inhibited by Dupilumab. EoL\u20101 cells expressed ITGA4 and adhered to recombinant CDH26 in vitro. Th2 cytokine stimulation enhanced EoL\u20101 cell transepithelial migration, which was significantly reduced by CDH26 knockdown or Dupilumab treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Th2 cytokine\u2010induced upregulation of epithelial CDH26 facilitates eosinophil transepithelial migration, potentially via ITGA4 interaction. Thus, CDH26 may represent a novel therapeutic target for managing eCRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70044","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:42:59Z","timestamp":1760557379000},"page":"138-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cadherin\u201026 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5344-5703","authenticated-orcid":false,"given":"Yeong\u2010In","family":"Jo","sequence":"first","affiliation":[{"name":"Upper Airway Chronic Inflammatory Diseases Laboratory Korea University College of Medicine  Seoul South Korea"},{"name":"Medical Device Usability Test Center Korea University Guro Hospital  Seoul South 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