{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:36:46Z","timestamp":1793655406598,"version":"4.5.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the therapeutic effects of acupuncture and sphenopalatine ganglion (SPG) needling for allergic rhinitis (AR) are well established, evidence for the efficacy of their combination remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, randomized, parallel\u2010controlled trial, 260 patients with persistent moderate\u2010to\u2010severe AR were assigned to 8 weeks of pharmacotherapy (MED; loratadine 10\u00a0mg\/day), acupuncture (ACU; 3 sessions\/week), sphenopalatine ganglion needling (SPG\u2010N; 1 session\/week), or combination therapy (COM, which received both acupuncture and SPG needling). The primary outcome was the response rate (\u226530% reduction in total nasal symptom score [TNSS]) at Week 8. Secondary outcomes included changes in TNSS, total non\u2010nasal symptom score (TNNSS), rhinoconjunctivitis quality of life questionnaire (RQLQ), and visual analogue scale (VAS) scores from baseline to Weeks 2, 4, 8, and the 4\u2010week follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At Week 8, response rates differed significantly among groups (COM: 82.54%; ACU: 71.43%; SPG\u2010N: 55.74%; MED: 45.31%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and were sustained at the 4\u2010week follow\u2010up. The COM showed the earliest significant improvement at Week 2 (63.49%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Compared to MED, both COM (relative risk [RR]\u00a0=\u00a01.90, 95% confidence interval [CI], 1.40\u20102.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and ACU (RR\u00a0=\u00a01.61, 95% CI, 1.18\u20132.21;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) were associated with significantly higher response rates at Week 8, whereas SPG\u2010N was not (RR\u00a0=\u00a01.27, 95% CI, 0.90\u20131.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.17).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that acupuncture combined with SPG needling provides more rapid, robust, and sustained symptomatic improvement in AR, offering an evidence\u2010based non\u2010pharmacologic alternative for AR management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70085","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T07:51:07Z","timestamp":1765957867000},"page":"380-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acupuncture Combined With Sphenopalatine Ganglion Needling for Allergic Rhinitis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0123-5157","authenticated-orcid":false,"given":"Shanshan","family":"Liu","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin 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