{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:21Z","timestamp":1790837061882,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health\u2010related quality of life and posing a safety hazard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210\u00a0mg or placebo subcutaneously every 4 weeks for 52 weeks. Changes from baseline in biweekly mean Nasal Polyposis Symptom Diary (NPSD) loss of smell item, University of Pennsylvania Smell Identification Test (UPSIT), and 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) loss of smell\/taste item scores, as well as anosmia (UPSIT score \u226418) prevalence, were assessed over 52 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 408 patients (tezepelumab [\n                      <jats:italic>n<\/jats:italic>\n                      = 203]; placebo [\n                      <jats:italic>n<\/jats:italic>\n                      = 205]), significant improvements with tezepelumab versus placebo in NPSD loss of smell item, UPSIT, and SNOT\u201022 loss of smell\/taste item scores were seen at week 4 (least\u2010squares mean [LSM] treatment difference [95% CI]: \u22120.36 [\u22120.46, \u22120.27]; 6.03 [4.72, 7.34]; and \u22121.01 [\u22121.22, \u22120.80], respectively) and week\u00a052 (\u22121.01 [\u22121.18, \u22120.83]; 9.50 [7.84, 11.16]; and \u22121.90 [\u22122.20, \u22121.61]); all nominal\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001. Between\u2010treatment differences in daily NPSD loss of smell item score were evident from day 7 (LSM treatment difference: \u22120.08 [95% CI: \u22120.15, \u22120.02]; nominal\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01). Improvements in NPSD loss of smell, UPSIT, and SNOT\u201022 loss of smell\/taste item scores were observed across multiple prespecified subgroups. Anosmia prevalence was lower with tezepelumab than placebo at week 4 (43.0% [\n                      <jats:italic>n\/N<\/jats:italic>\n                      = 64\/149] vs. 80.3% [\n                      <jats:italic>n\/N<\/jats:italic>\n                      = 106\/132]) and week 52 (31.5% [\n                      <jats:italic>n\/N<\/jats:italic>\n                      = 47\/149] vs. 75.8% [\n                      <jats:italic>n\/N<\/jats:italic>\n                      = 100\/132]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tezepelumab provides early and sustained improvements in sense of smell among patients with uncontrolled CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70090","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:12:32Z","timestamp":1767697952000},"page":"484-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5007","authenticated-orcid":false,"given":"Joaquim","family":"Mullol","sequence":"first","affiliation":[{"name":"Rhinology Unit &amp; Smell Clinic Department of Otorhinolaryngology Hospital Clinic Barcelona IDIBAPS CIBERES University of Barcelona  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck 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Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pfaar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-2959","authenticated-orcid":false,"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Centre Hospitalier de L'Universit\u00e9 de Montr\u00e9al University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Brigham and Women's Hospital Harvard Medical School  Boston 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